The effect of alpha-tocopheryl succinate on succinate respiration in rat liver mitochondria

0457718 - FGÚ 2016 RIV CZ eng J - Journal Article
Sobotka, O. - Drahota, Zdeněk - Kučera, O. - Endlicher, R. - Rauchová, Hana - Červinková, Z.
The effect of alpha-tocopheryl succinate on succinate respiration in rat liver mitochondria.
Physiological Research. Roč. 64, Suppl.5 (2015), S609-S615. ISSN 0862-8408. E-ISSN 1802-9973
Institutional support: RVO:67985823
Keywords : tocopheryl succinate * Complex II * liver * mitochondria * homogenate * hepatocytes
Subject RIV: ED - Physiology
Impact factor: 1.643, year: 2015

We compared the effect of alpha-tocopheryl succinate (TOS) on
succinate-dependent respiration in rat liver mitochondria,
homogenate and permeabilized hepatocytes in both a coupled
and uncoupled state. In isolated mitochondria, a significant
inhibitory effect was observed at a concentration of 5 µM, in liver
homogenate at 25 µM and in permeabilized hepatocytes at
50 µM. The inhibitory effect of TOS on succinate respiration in an
uncoupled state was less pronounced than in a coupled state in
all the experimental models tested. When the concentration
dependence of the TOS inhibitory effect was tested, the most
sensitive in both states were isolated mitochondria; the most
resistant were permeabilized hepatocytes

Permanent Link: http://hdl.handle.net/11104/0258085