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Structure-dependent NO-, PGE2- and cytokine-inhibitory effects of pyrimidine derivatives
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SYSNO ASEP 0442265 Document Type C - Proceedings Paper (int. conf.) R&D Document Type The record was not marked in the RIV Title Structure-dependent NO-, PGE2- and cytokine-inhibitory effects of pyrimidine derivatives Author(s) Zídek, Zdeněk (UEM-P)
Kmoníčková, Eva (UEM-P) RID
Janeba, Zlatko (UOCHB-X) RID, ORCID
Kolman, Viktor (UOCHB-X) RID
Jansa, Petr (UOCHB-X) RIDNumber of authors 5 Source Title Proceedings of the Joint Meeting of the 8th International Symposium Nitric Oxide. - : organizátor symposia, 2014 - ISBN 978-80-971699-0-9 Pages s. 6-10 Number of pages 5 s. Action Proceedings of the Joint Meeting of the 8th International Symposium Nitric Oxide: From Basic Regulations to Lifestyle-Related Diseases and The 2nd Genetic and Environmental Factors in Hypertension [0312302] Event date 15.09.2014-19.09.2014 VEvent location Vrsan Country HR - Croatia Event type EUR Language eng - English Country HR - Croatia Keywords PGE2 ; TNF-a ; pyrimidine derivatives Subject RIV FR - Pharmacology ; Medidal Chemistry R&D Projects GAP303/12/0172 GA ČR - Czech Science Foundation (CSF) Institutional support UEM-P - RVO:68378041 ; UOCHB-X - RVO:61388963 Annotation We synthesized novel series of pyrimidine derivatives. Besides NO, the pyrimidine derivatives suppressed, though less effectively, the production of PGE2 and TNF-a. The data on mouse peritoneal cells suggest that the immunosuppressive properties of pyrimidines depend mainly on the presence of the 4,6-dichloropyrimidine scaffold. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2015
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