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Sulfo-N-succinimidyl Oleate (SSO) Inhibits Fatty Acid Uptake and Signaling for Intracellular Calcium via Binding CD36 Lysine 164
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SYSNO ASEP 0396909 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Sulfo-N-succinimidyl Oleate (SSO) Inhibits Fatty Acid Uptake and Signaling for Intracellular Calcium via Binding CD36 Lysine 164 Author(s) Kuda, Ondřej (FGU-C) RID, ORCID, SAI
Pietka, T. A. (US)
Demianova, Zuzana (UOCHB-X)
Kudová, Eva (UOCHB-X) RID, ORCID
Cvačka, Josef (UOCHB-X) RID, ORCID
Kopecký, Jan (FGU-C) RID, ORCID
Abumrad, N. A. (US)Source Title Journal of Biological Chemistry. - : Elsevier - ISSN 0021-9258
Roč. 288, č. 22 (2013), s. 15547-15555Number of pages 9 s. Language eng - English Country US - United States Keywords CD36 ; sulfo-N-succinimidyl oleate ; mass spectrometry Subject RIV FB - Endocrinology, Diabetology, Metabolism, Nutrition Subject RIV - cooperation Institute of Organic Chemistry and Biochemistry - Biochemistry R&D Projects 7E12073 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GP13-04449P GA ČR - Czech Science Foundation (CSF) Institutional support FGU-C - RVO:67985823 ; UOCHB-X - RVO:61388963 UT WOS 000319822300013 EID SCOPUS 84878420190 DOI 10.1074/jbc.M113.473298 Annotation Mechanism of CD36 inhibition by sulfo-N-succinimidyl oleate (SSO) was explored using mass spectrometry and mutagenesis. SSO binds lysine 164 and inhibits uptake of fatty acids and oxLDL. Lysine 164 is important for CD36-mediated fatty acid uptake and Ca2+signaling. Fatty acids and oxLDL bind to the same site within a hydrophobic pocket of CD36 shared by several lipid ligands Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2014
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