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Ca2+ sensitization and Ca2+ entry in the control of blood pressure and adrenergic vasoconstriction in conscious Wistar-Kyoto and spontaneously hypertensive rats
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SYSNO ASEP 0396903 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Ca2+ sensitization and Ca2+ entry in the control of blood pressure and adrenergic vasoconstriction in conscious Wistar-Kyoto and spontaneously hypertensive rats Author(s) Behuliak, Michal (FGU-C) RID, ORCID
Pintérová, Mária (FGU-C)
Bencze, Michal (FGU-C) RID, ORCID, SAI
Petrová, M. (SK)
Líšková, Silvia (FGU-C)
Karen, Petr (FGU-C)
Kuneš, Jaroslav (FGU-C) RID, ORCID
Vaněčková, Ivana (FGU-C) RID, ORCID
Zicha, Josef (FGU-C) RID, ORCID, SAISource Title Journal of Hypertension. - : Lippincott Williams & Wilkins - ISSN 0263-6352
Roč. 31, č. 10 (2013), s. 2025-2035Number of pages 11 s. Language eng - English Country GB - United Kingdom Keywords Ca2+ influx ; nifedipine ; RhoA/Rho kinase ; fasudil ; sympathetic vasoconstriction Subject RIV FA - Cardiovascular Diseases incl. Cardiotharic Surgery R&D Projects 1M0510 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GA305/09/0336 GA ČR - Czech Science Foundation (CSF) GAP304/12/0259 GA ČR - Czech Science Foundation (CSF) Institutional support FGU-C - RVO:67985823 CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000326589700017 EID SCOPUS 84884401657 DOI 10.1097/HJH.0b013e328362adb3 Annotation The participation of calcium entry and calcium sensitization in the control of blood pressure (BP) and vascular contraction was studied in SHR and normotensive WKY rats. Ca2+ sensitization mediated by RhoA/Rho kinase pathway is attenuated in SHR compared to normotensive WKY rats. This might be a part of the compensation for enhanced Ca2+ entry through L-VDCC in genetic hypertension Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2014
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