Supramolecular approach for target transport of photodynamic anticancer agents

0390203 - ÚMG 2013 RIV GB eng J - Journal Article
Kejík, Z. - Kaplánek, R. - Bříza, T. - Králová, Jarmila - Martásek, P. - Král, V.
Supramolecular approach for target transport of photodynamic anticancer agents.
Supramolecular Chemistry. Roč. 24, č. 2 (2012), s. 106-116. ISSN 1061-0278. E-ISSN 1029-0478
R&D Projects: GA MŠMT(CZ) LC06077; GA MŠMT(CZ) 1M0520; GA ČR(CZ) GAP303/11/1291; GA ČR GA203/09/1311
Institutional research plan: CEZ:AV0Z50520514
Keywords : photodynamic therapy * photosensitisers * targeted transport * combination therapy * cancer
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 1.546, year: 2012

Photodynamic therapy (PDT) is one of the most modern methods for cancer therapy. Various types of advanced photosensitisers (PSs) have been developed for effective application in PDT. Current research has started to demonstrate the high importance of targeted PS transport and subcellular localisation for the effective destruction of tumours. Another possible approach for the improvement of PDT is the use of synergic PS for combination anticancer therapy. The implementation of a supramolecular approach is necessary for their effective design. This can be achieved through the use of PS as non-covalent complexes with suitable carriers such as human serum albumin, lectins, cyclodextrins, polysaccharides, lipoproteins, liposomes, intravenous immunoglobulins and polymeric micelles. In addition, some of these carriers have their own anticancer activity. An alternative approach can be the use of PS for the transport of other anticancer agents. Therefore, this minireview focuses on describing these supramolecular PS systems for targeted transport and combination therapy.
Permanent Link: http://hdl.handle.net/11104/0219113