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Superhelical DNA as a preferential binding target of 14-3-3 gamma protein
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SYSNO ASEP 0389526 Document Type J - Journal Article R&D Document Type The record was not marked in the RIV Subsidiary J Článek ve WOS Title Superhelical DNA as a preferential binding target of 14-3-3 gamma protein Title Superhelical DNA as a preferential binding target of 14-3-3 gamma protein Author(s) Brázda, Václav (BFU-R) RID, ORCID
Čechová, J. (CZ)
Coufal, Jan (BFU-R) ORCID
Rumpel, S. (CA)
Jagelská, Eva (BFU-R)Number of authors 5 Source Title Journal of Biomolecular Structure & Dynamics. - : Taylor & Francis - ISSN 0739-1102
Roč. 30, č. 4 (2012), s. 371-378Number of pages 8 s. Publication form Print - P Language eng - English Country US - United States Keywords TUMOR-SUPPRESSOR P53 ; ASSOCIATES IN-VIVO ; SUPERCOILED DNA Subject RIV BO - Biophysics Subject RIV - cooperation Biophysics R&D Projects 301/10/1211 GA ČR - Czech Science Foundation (CSF) LC 06035 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) M200040904 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) Institutional support BFU-R - RVO:68081707 UT WOS 000308104100001 Annotation The 14-3-3 protein family is a highly conserved and widely distributed group of proteins consisting of multiple isoforms in eukaryotes. Ubiquitously expressed, 14-3-3 proteins play key roles in DNA replication, cell cycle regulation, and apoptosis. The function of 14-3-3 proteins is mediated by interaction with a large number of other proteins and with DNA. It has been demonstrated that 14-3-3 gamma protein binds strongly to cruciform structures and is crucial for initiating replication. In this study, we analyzed DNA binding properties of the 14-3-3 gamma isoform to linear and supercoiled DNA. Description in English The 14-3-3 protein family is a highly conserved and widely distributed group of proteins consisting of multiple isoforms in eukaryotes. Ubiquitously expressed, 14-3-3 proteins play key roles in DNA replication, cell cycle regulation, and apoptosis. The function of 14-3-3 proteins is mediated by interaction with a large number of other proteins and with DNA. It has been demonstrated that 14-3-3 gamma protein binds strongly to cruciform structures and is crucial for initiating replication. In this study, we analyzed DNA binding properties of the 14-3-3 gamma isoform to linear and supercoiled DNA. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2013
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