Ontogenetic Development of GABA(B)-Receptor Signaling Cascade in Plasma Membranes Isolated From Rat Brain Cortex; the Number of GABA(B)-Receptors Is High Already Shortly After the Birth

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SYSNO ASEP	0388553
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Ontogenetic Development of GABA(B)-Receptor Signaling Cascade in Plasma Membranes Isolated From Rat Brain Cortex; the Number of GABA(B)-Receptors Is High Already Shortly After the Birth
Author(s)	Kagan, Dmytro (FGU-C) Dlouhá, Kateřina (FGU-C) Roubalová, Lenka (FGU-C)_{RID, ORCID, SAI} Svoboda, Petr (FGU-C)_{RID, ORCID}
Source Title	Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408 Roč. 61, č. 6 (2012), s. 629-635
Number of pages	7 s.
Language	eng - English
Country	CZ - Czech Republic
Keywords	postnatal development ; GABAB-receptors ; G-protein coupling/activation ; baclofen ; SKF97541
Subject RIV	CE - Biochemistry
R&D Projects	GBP304/12/G069 GA ČR - Czech Science Foundation (CSF)
	GAP207/12/0919 GA ČR - Czech Science Foundation (CSF)
Institutional support	FGU-C - RVO:67985823
CEZ	AV0Z50110509 - FGU-C (2005-2011)
UT WOS	000314138600008
Annotation	Our data indicate the significant intrinsic efficacy of GABAB-receptors in rat brain cortex already at birth (PD1, PD2). The potency of G-protein response to baclofen (characterized by EC50 values) was also high at birth but unchanged by further postnatal development. The highest plasma membrane density of GABAB-R was measured in 1-day old animals
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2013

Number of the records: 1