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Ontogenetic Development of GABA(B)-Receptor Signaling Cascade in Plasma Membranes Isolated From Rat Brain Cortex; the Number of GABA(B)-Receptors Is High Already Shortly After the Birth
- 1.0388553 - FGÚ 2013 RIV CZ eng J - Journal Article
Kagan, Dmytro - Dlouhá, Kateřina - Roubalová, Lenka - Svoboda, Petr
Ontogenetic Development of GABA(B)-Receptor Signaling Cascade in Plasma Membranes Isolated From Rat Brain Cortex; the Number of GABA(B)-Receptors Is High Already Shortly After the Birth.
Physiological Research. Roč. 61, č. 6 (2012), s. 629-635. ISSN 0862-8408. E-ISSN 1802-9973
R&D Projects: GA ČR(CZ) GBP304/12/G069; GA ČR(CZ) GAP207/12/0919
Institutional research plan: CEZ:AV0Z50110509
Institutional support: RVO:67985823
Keywords : postnatal development * GABAB-receptors * G-protein coupling/activation * baclofen * SKF97541
Subject RIV: CE - Biochemistry
Impact factor: 1.531, year: 2012
Our data indicate the significant intrinsic efficacy of GABAB-receptors in rat brain cortex already at birth (PD1, PD2). The potency of G-protein response to baclofen (characterized by EC50 values) was also high at birth but unchanged by further postnatal development. The highest plasma membrane density of GABAB-R was measured in 1-day old animals
Permanent Link: http://hdl.handle.net/11104/0217456
Number of the records: 1