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Sperm Cells Induce Distinct Cytokine Response in Peripheral Mononuclear Cells from Infertile Women with Serum Anti-Sperm Antibodies
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SYSNO ASEP 0382246 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Sperm Cells Induce Distinct Cytokine Response in Peripheral Mononuclear Cells from Infertile Women with Serum Anti-Sperm Antibodies Author(s) Kverka, Miloslav (MBU-M) RID, ORCID
Ulčová-Gallová, Z. (CZ)
Bártová, J. (CZ)
Cibulka, J. (CZ)
Bibková, K. (CZ)
Mičanová, Z. (CZ)
Tlaskalová-Hogenová, Helena (MBU-M) RID, ORCIDSource Title PLoS ONE. - : Public Library of Science - ISSN 1932-6203
Roč. 7, č. 8 (2012), e44172Number of pages 6 s. Language eng - English Country US - United States Keywords IMMUNE-RESPONSES ; GROWTH-FACTOR ; ENDOMETRIOSIS Subject RIV EC - Immunology Institutional support MBU-M - RVO:61388971 UT WOS 000308221300058 DOI 10.1371/journal.pone.0044172 Annotation Anti-sperm antibodies in can markedly reduce the likelihood of natural conception. The etiology of this anti-sperm immunity in human females is unknown. We compared the cytokine response of peripheral blood mononuclear cells (PBMCs) from infertile patients with or without anti-sperm antibodies (ASA) and fertile women.Cellular immune responses to sperm antigens, measured by production of cytokines, differ among infertile women with ASA, infertile women without ASA and healthy women. This difference could play an important role in the initial steps of the infertility pathogenesis. Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2013
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