Transfer of heparin polyion across a polarized water/ionic liquid membrane interface

0379900 - ÚFCH JH 2013 RIV NL eng J - Journal Article
Langmaier, Jan - Samec, Zdeněk - Samcová, E. - Tůma, P.
Transfer of heparin polyion across a polarized water/ionic liquid membrane interface.
Electrochemistry Communications. Roč. 24, OCT 2012 (2012), s. 25-27. ISSN 1388-2481. E-ISSN 1873-1902
R&D Projects: GA ČR GAP206/11/0707
Institutional support: RVO:61388955
Keywords : heparin polyion * ionic liquid membrane * amperometric detection
Subject RIV: CG - Electrochemistry
Impact factor: 4.425, year: 2012

Cyclic voltammetry is used to investigate the transfer of heparin polyion across the interface between water and the ionic liquid (IL) membrane composed of tridodecylmethylammonium cation (TDMA+) and tetrakis[3,5-bis(trifluoromethyl) phenyl]borate anion (TFPB−). Study reveals a tunable effect of the semihydrophobic tetraalkylammonium cations (TAA+) present at trace concentrations in the aqueous solution containing heparin. Theoretical considerations based on the mixed-potential concept and experimental evidence suggest that the TAA+ cations promote the extraction of heparin into the IL phase, from which heparin can be stripped off by applied potential providing a well-separated current signal. A new method for the amperometric detection of heparin is proposed.
Permanent Link: http://hdl.handle.net/11104/0210756