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Is formamide nature’s choice to create life? Comment on the paper “Formamide and the origin of life“ by Raffaele Saladino et al
- 1.0378737 - BFÚ 2013 RIV US eng J - Journal Article
Šponer, Judit E. - Šponer, Jiří
Is formamide nature’s choice to create life? Comment on the paper “Formamide and the origin of life“ by Raffaele Saladino et al.
Physics of Life Reviews. Roč. 9, č. 1 (2012), s. 109-110. ISSN 1571-0645. E-ISSN 1873-1457
R&D Projects: GA MŠMT(CZ) LC06030; GA AV ČR(CZ) IAA400040802; GA ČR(CZ) GAP208/10/2302; GA ČR(CZ) GA203/09/1476; GA ČR(CZ) GAP208/11/1822
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : formamide * prebiotic synthesis * nucleobase
Subject RIV: BO - Biophysics
Impact factor: 6.583, year: 2012
We have carried out a detailed quantum chemical characterization of the kinetics of the Saladino-synthesis and illuminated the role of catalytic water molecules. We have found that addition of HCN to formamide dimer requires water-assistance: otherwise the reaction would require much harsher conditions than those reported by Saladino et al. The calculated activation energies fully support the prebiotic plausibility of the synthetic route via formamide dimer proposed by Saladino et al., which “entirely compatible with an alkaline hydrothermal vents scenario”.
Permanent Link: http://hdl.handle.net/11104/0210137
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