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Inhibitors of Succinate: Quinone Reductase/Complex II Regulate Production of Mitochondrial Reactive Oxygen Species and Protect Normal Cells from Ischemic Damage but Induce Specific Cancer Cell Death
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SYSNO ASEP 0369494 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Inhibitors of Succinate: Quinone Reductase/Complex II Regulate Production of Mitochondrial Reactive Oxygen Species and Protect Normal Cells from Ischemic Damage but Induce Specific Cancer Cell Death Author(s) Ralph, S.J. (AU)
Moreno-Sanchez, R. (MX)
Neužil, Jiří (BTO-N) RID
Rodriguez-Enriquez, S. (MX)Source Title Pharmaceutical Research. - : Springer - ISSN 0724-8741
Roč. 28, č. 11 (2011), s. 2695-2730Number of pages 35 Language eng - English Country US - United States Keywords Mitocans ; SDH/Complex II ; mitochondrial ROS production Subject RIV CE - Biochemistry CEZ AV0Z50520701 - BTO-N (2007-2013) UT WOS 000295697700006 DOI 10.1007/s11095-011-0566-7 Annotation Succinate:quinone reductase (SQR) of Complex II, occupying a unique central point in the mitochondrial respiratory system as a major source of electrons driving reactive oxygen species (ROS) production, is an ideal pharmaceutical target for modulating ROS levels in normal cells to prevent oxidative stress-induced damage or increase ROS in cancer cells, inducing cell death. Value of drugs like diazoxide to prevent ROS production, protecting normal cells, while vitamin E analogues promote ROS in cancer cells to kill them, is highlighted. We collate and discuss diverse sources of information relating to ROS production in different biological systems, focussing on evidence for SQR as main source of ROS production in mitochondria, particularly its relevance to protection from oxidative stress and to mitochondrial-targeted anticancer drugs (mitocans) as novel cancer therapies. Workplace Institute of Biotechnology Contact Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Year of Publishing 2012
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