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HIF1 Pathways in Diabetic Embryopathy
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SYSNO ASEP 0355319 Document Type C - Proceedings Paper (int. conf.) R&D Document Type The record was not marked in the RIV Title HIF1 Pathways in Diabetic Embryopathy Author(s) Pavlínková, Gabriela (BTO-N) RID, ORCID
Bohuslavová, Romana (BTO-N) RID
Kuthanová, Lada (BTO-N)
Salbaum, M. (US)
Kappen, C. (US)Source Title Hypoxia: Molecular mechanisms of Oxygen Sensing and Response Pathways. - Colorado : Keystone Resort, 2010 Pages s. 99-99 Number of pages 1 s. Action Keystone Symposia on Molecular and Cellular Biology Event date 19.01.2010-24.01.2010 VEvent location Colorado Country US - United States Event type WRD Language eng - English Country US - United States Keywords diabetic embryopathy Subject RIV FB - Endocrinology, Diabetology, Metabolism, Nutrition CEZ AV0Z50520701 - BTO-N (2007-2013) Annotation Maternal diabetes negatively affects the normal embryonic development causing diabetic embryopathy in humans. The most prominent congenital malformations associated with diabetic embryopathy are neural tube defects, cardiovascular defects, and caudal dysgenessis. Using the mouse as an experimental system and global gene expression profiling, we have found that altered transcriptional regulation plays a major role in the response of embryos to intrauterine exposure to diabetic conditions. One of the diabetes-deregulated transcription factors was Hypoxia inducible factor 1 alpha (Hif1α). In addition, the expression of 22 known HIF1 target genes was significantly altered in diabetes-exposed embryos compared to controls. The critical role of Hif1α pathways in embryonic development was demonstrated by the Hif1α homozygous null mutation. Hif1α-/- knockout embryos die around midgestation because of severe cardiovascular and neural tube defects Workplace Institute of Biotechnology Contact Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Year of Publishing 2011
Number of the records: 1