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Screening for acetylcholinesterase inhibitory activity in cyanobacteria of the genus Nostoc
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SYSNO ASEP 0316713 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Screening for acetylcholinesterase inhibitory activity in cyanobacteria of the genus Nostoc Title Screening inhibitorů acetylcholinesterasy u sinic rodu Nostoc Author(s) Zelík, Petr (MBU-M)
Lukešová, Alena (BC-A) RID, ORCID
Voloshko, L. N. (RU)
Štys, D. (CZ)
Kopecký, Jiří (MBU-M) ORCIDSource Title Journal of Enzyme Inhibition and Medicinal Chemistry. - : Taylor & Francis - ISSN 1475-6366
Roč. 24, č. 2 (2009), s. 531-536Number of pages 6 s. Language eng - English Country GB - United Kingdom Keywords acetylcholinesterase ; bioactivity ; inhibitors Subject RIV EE - Microbiology, Virology R&D Projects ME 874 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50200510 - MBU-M (2005-2011) AV0Z60660521 - UPB-H, BC-A (2005-2011) UT WOS 000264203100028 DOI 10.1080/14756360802234836 Annotation Fifty-four cyanobacterial strains of the genus Nostoc from different habitats were screened for acetylcholinesterase (AChE) inhibitory activity. AChE inhibitory activity higher than 80 % was found in the crude extracts of the six Nostoc strains. Moderate AChE inhibitory activity over 40 % was found in seven Nostoc extracts. The chemical structure of the active metabolite responsible for acetylcholinesterase inhibition was identified in a crude extract of Nostoc sp. str. Lukešová 27/97 by using of various instrumental techniques (UV and IR spectroscopy, HPLC/DAD/MS, NMR, X-ray crystallography) Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2009
Number of the records: 1