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Thermoresponsive polymer for local radiotherapy with doxorubicin bound via a newly developed hydrolytically labile bond
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SYSNO ASEP 0306669 Document Type C - Proceedings Paper (int. conf.) R&D Document Type Conference Paper Title Thermoresponsive polymer for local radiotherapy with doxorubicin bound via a newly developed hydrolytically labile bond Title Termoresponsivní polymery pro lokální radioterapii s doxorubicinem vázaným nově vyvinutou hydrolyticky labilní vazbou Author(s) Hrubý, Martin (UMCH-V) RID, ORCID
Kučka, Jan (UJF-V) RID
Koňák, Čestmír (UMCH-V) RID
Větřík, M. (CZ)
Lebeda, Ondřej (UJF-V) RID, ORCID, SAI
Ulbrich, Karel (UMCH-V) RIDSource Title Abstract Book - Tenth European Symposium on Controlled Drug Delivery. - Noordwijk aan Zee : University of Twente, 2008 / Sam A.P. - ISBN 978-90-365-2653-1 Pages s. 174-177 Number of pages 4 s. Action European Symposium on Controlled Drug Delivery /10./ Event date 02.04.2008-04.04.2008 VEvent location Noordwijk aan Zee Country NL - Netherlands Event type WRD Language eng - English Country NL - Netherlands Keywords thermoresponsive ; local ; radiotherapy Subject RIV CD - Macromolecular Chemistry R&D Projects IAA400480616 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) KAN200200651 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z40500505 - UMCH-V (2005-2011) AV0Z10480505 - UJF-V (2005-2011) Annotation A new polymeric drug delivery system designed for possible local chemoradiotherapy using injectable thermoresponsive polymer with radionuclide and doxorubicin, which serves as an antiproliferative agent and hydrophobic moiety controlling bioerosion in the same time, was synthesized and characterized. Doxorubicin is bound to the polymer carrier by a newly developed N-glycosylamine bond. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2008
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