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Synthesis of nucleoside 5'-S-methylphosphonates and related compounds
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SYSNO ASEP 0312432 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Synthesis of nucleoside 5'-S-methylphosphonates and related compounds Title Syntéza nukleosid 5'-S-metylfosfonátů a souvisejících sloučenin Author(s) Markusová Kóšiová, Ivana (UOCHB-X) RID, ORCID
Rosenberg, Ivan (UOCHB-X) RID, ORCIDSource Title Nucleic Acids Symposium Series - ISSN 0261-3166
-, č. 52 (2008), s. 569-570Number of pages 2 s. Action Joint Symposium of the International Roundtable on Nucleosides, Nucleotides and Nucleic Acids /18./ and the International Symposium on Nucleic Acid Chemistry /35./ Event date 08.09.2008-12.09.2008 VEvent location Kyoto Country JP - Japan Event type WRD Language eng - English Country GB - United Kingdom Keywords nucleotide ; S'-methylphosphonate analog Subject RIV CC - Organic Chemistry R&D Projects LC06061 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LC06077 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z40550506 - UOCHB-X (2005-2011) DOI https://doi.org/10.1093/nass/nrn288 Annotation Phosphonate analogs of mono- and oligonucleotides with the P-C-O-C5' moiety have interesting biochemical and biophysical properties. A series of novel compounds, S-methylphosphonate-based nucleotides, with the P-C-S-C5' linkage was prepared as monomers for solid phase synthesis of modified oligonucleotides. Replacement of the 5'-oxygen atom with more nucleophilic, bulky, and lipophilic sulfur atom may influence the physicochemical and biological properties of nucleoside 5'-S-methylphosphonates and chimeric oligonucleotides as well. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2009
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