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Fully synthetic, tunable poly(alpha-amino acids) as the base of bioinks curable by visible light
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SYSNO ASEP 0585861 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Fully synthetic, tunable poly(alpha-amino acids) as the base of bioinks curable by visible light Author(s) Golunova, Anna (UMCH-V) RID, ORCID
Dvořáková, Jana (UMCH-V) RID, ORCID
Velychkivska, Nadiia (UMCH-V) RID, ORCID
Strachota, Beata (UMCH-V) RID
Dydowiczová, Aneta (UMCH-V) ORCID
Trousil, Jiří (UMCH-V) RID, ORCID
Proks, Vladimír (UMCH-V) RID, ORCIDArticle number 035035 Source Title Biomedical Materials. - : Institute of Physics Publishing - ISSN 1748-6041
Roč. 19, č. 3 (2024)Number of pages 15 s. Language eng - English Country US - United States Keywords bioprinting ; hydrogels ; photogelation Subject RIV CD - Macromolecular Chemistry OECD category Polymer science R&D Projects GA21-06524S GA ČR - Czech Science Foundation (CSF) Method of publishing Limited access Institutional support UMCH-V - RVO:61389013 UT WOS 001208627400001 EID SCOPUS 85191466904 DOI https://doi.org/10.1088/1748-605X/ad3f62 Annotation Bioinks play a crucial role in tissue engineering, influencing mechanical and chemical properties of the printed scaffold as well as the behavior of encapsulated cells. Recently, there has been a shift from animal origin materials to their synthetic alternatives. In this context, we present here bioinks based on fully synthetic and biodegradable poly(α,L-amino acids) (PolyAA) as an alternative to animal-based gelatin methacrylate (Gel-Ma) bioinks. Additionally, we first reported the possibility of the visible light photoinitiated incorporation of the bifunctional cell adhesive RGD peptide into the PolyAA hydrogel matrix. The obtained hydrogels are shown to be cytocompatible, and their mechanical properties closely resemble those of gelatin methacrylate-based scaffolds. Moreover, combining the unique properties of PolyAA-based bioinks, the photocrosslinking strategy, and the use of droplet-based printing allows the printing of constructs with high shape fidelity and structural integrity from low-viscosity bioinks without using any sacrificial components. Overall, presented PolyAA-based materials are a promising and versatile toolbox that extends the range of bioinks for droplet bioprinting. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2025 Electronic address https://iopscience.iop.org/article/10.1088/1748-605X/ad3f62
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