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The crucial role of HIF-1α and mitophagy in cardioprotection induced by chronic hypoxia
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SYSNO ASEP 0583517 Document Type A - Abstract R&D Document Type O - Ostatní Title The crucial role of HIF-1α and mitophagy in cardioprotection induced by chronic hypoxia Author(s) Opletalová, Barbora (FGU-C)
Alán, Lukáš (FGU-C) RID, ORCID
Bohuslavová, Romana (BTO-N) RID
Holzerová, Kristýna (FGU-C) ORCID, RID
Di Lisa, F. (IT)
Pavlínková, Gabriela (BTO-N) RID, ORCID
Kolář, František (FGU-C) RID, ORCID, SAI
Alánová, Petra (FGU-C) RID, ORCIDSource Title Abstract book - 7th International PhD Student Conference Nencki Institute of Experimental Biology. - Warsaw : Nencki Institute of Experimental Biology, 2023
S. 46-46Number of pages 1 s. Action International PhD Student Conference /7./ Event date 19.10.2023 - 20.10.2023 VEvent location Warsaw Country PL - Poland Event type WRD Language eng - English Country PL - Poland Keywords chronic hypoxia ; HIF-1α ; mitochondria OECD category Cardiac and Cardiovascular systems R&D Projects LX22NPO5104 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support FGU-C - RVO:67985823 ; BTO-N - RVO:86652036 Annotation We found a significant difference in the levels of proteins associated with mitophagy, such as LC3II/LC3I, p62, PINK1, Drp1. Our data suggest that HIF-1α is crucial for CH-induced myocardial protection against I/R injury likely by altering mitochondrial function and activation of mitophagy. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2024 Electronic address https://nencki.edu.pl/7th-international-phd-student-conference/
Number of the records: 1