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The crucial role of HIF-1α and mitophagy in cardioprotection induced by chronic hypoxia

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    SYSNO ASEP0583517
    Document TypeA - Abstract
    R&D Document TypeO - Ostatní
    TitleThe crucial role of HIF-1α and mitophagy in cardioprotection induced by chronic hypoxia
    Author(s) Opletalová, Barbora (FGU-C)
    Alán, Lukáš (FGU-C) RID, ORCID
    Bohuslavová, Romana (BTO-N) RID
    Holzerová, Kristýna (FGU-C) ORCID, RID
    Di Lisa, F. (IT)
    Pavlínková, Gabriela (BTO-N) RID, ORCID
    Kolář, František (FGU-C) RID, ORCID, SAI
    Alánová, Petra (FGU-C) RID, ORCID
    Source TitleAbstract book - 7th International PhD Student Conference Nencki Institute of Experimental Biology. - Warsaw : Nencki Institute of Experimental Biology, 2023
    S. 46-46
    Number of pages1 s.
    ActionInternational PhD Student Conference /7./
    Event date19.10.2023 - 20.10.2023
    VEvent locationWarsaw
    CountryPL - Poland
    Event typeWRD
    Languageeng - English
    CountryPL - Poland
    Keywordschronic hypoxia ; HIF-1α ; mitochondria
    OECD categoryCardiac and Cardiovascular systems
    R&D ProjectsLX22NPO5104 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
    Institutional supportFGU-C - RVO:67985823 ; BTO-N - RVO:86652036
    AnnotationWe found a significant difference in the levels of proteins associated with mitophagy, such as LC3II/LC3I, p62, PINK1, Drp1. Our data suggest that HIF-1α is crucial for CH-induced myocardial protection against I/R injury likely by altering mitochondrial function and activation of mitophagy.
    WorkplaceInstitute of Physiology
    ContactLucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
    Year of Publishing2024
    Electronic addresshttps://nencki.edu.pl/7th-international-phd-student-conference/
Number of the records: 1  

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