Phototriggered cytotoxicity of ferrocene-based micelles - a nonconventional approach to phototherapy

0582432 - ÚMCH 2025 RIV US eng J - Journal Article
Hoang, Stéphane - Vandamme, M. - Pinna, G. - Miserque, F. - Kučka, Jan - Šefc, L. - Štěpánek, Petr - Doris, E. - Hrubý, Martin - Gravel, E.
Phototriggered cytotoxicity of ferrocene-based micelles - a nonconventional approach to phototherapy.
ACS Applied Materials and Interfaces. Roč. 16, č. 5 (2024), s. 5666-5676. ISSN 1944-8244. E-ISSN 1944-8252
R&D Projects: GA ČR(CZ) GA21-01090S; GA MZd(CZ) NU22-03-00318; GA MŠMT(CZ) LM2023053
Research Infrastructure: Czech-BioImaging III - 90250
Institutional support: RVO:61389013
Keywords : micelles * ferrocene * phototherapy
OECD category: Polymer science
Impact factor: 9.5, year: 2022
Method of publishing: Limited access
https://pubs.acs.org/doi/10.1021/acsami.3c17673

We report the design, synthesis, and in vitro evaluation of stimuli-responsive nanoscale micelles that can be activated by light to induce a cytotoxic effect. Micelles were assembled from amphiphilic units made of a photoactivatable ferrocenyl linker, connected on one side to a lipophilic chain, and on the other side to a hydrophilic pegylated chain. In vitro experiments indicated that pristine micelles (“off” state) were nontoxic to MCF-7 cancer cells, even at high concentrations, but became potent upon photoactivation (“on” state). The illumination process led to the dissociation of the micelles and the concomitant release of iron species, triggering cytotoxicity.
Permanent Link: https://hdl.handle.net/11104/0351132