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Low oral dose of 4-methylumbelliferone reduces glial scar but is insufficient to induce functional recovery after spinal cord injury
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SYSNO ASEP 0582287 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Low oral dose of 4-methylumbelliferone reduces glial scar but is insufficient to induce functional recovery after spinal cord injury Author(s) Štěpánková, K. (CZ)
Chudičková, M. (CZ)
Šimková, Z. (CZ)
Martinez-Varea, N. (CZ)
Kubinová, Šárka (FZU-D) RID, ORCID
Machová-Urdzíková, L. (CZ)
Jendelová, P. (CZ)
Kwok, J. C. F. (CZ)Number of authors 8 Article number 19183 Source Title Scientific Reports. - : Nature Publishing Group - ISSN 2045-2322
Roč. 13, č. 1 (2023)Number of pages 19 s. Language eng - English Country US - United States Keywords low oral dose ; 4-methylumbelliferone ; reduces glial scar ; induce functional recovery ; after spinal cord injury Subject RIV FH - Neurology OECD category Pharmacology and pharmacy Method of publishing Open access Institutional support FZU-D - RVO:68378271 UT WOS 001108929300081 EID SCOPUS 85175837647 DOI 10.1038/s41598-023-46539-5 Annotation Spinal cord injury (SCI) induces the upregulation of chondroitin sulfate proteoglycans (CSPGs) at the glial scar and inhibits neuroregeneration. Under normal physiological condition, CSPGs interact with hyaluronan (HA) and other extracellular matrix on the neuronal surface forming a macromolecular structure called perineuronal nets (PNNs) which regulate neuroplasticity. 4-methylumbelliferone (4-MU) is a known inhibitor for HA synthesis but has not been tested in SCI. We first tested the effect of 4-MU in HA reduction in uninjured rats. After 8 weeks of 4-MU administration at a dose of 1.2 g/kg/day, we have not only observed a reduction of HA in the uninjured spinal cords but also a down-regulation of CS glycosaminoglycans (CS-GAGs). Workplace Institute of Physics Contact Kristina Potocká, potocka@fzu.cz, Tel.: 220 318 579 Year of Publishing 2024 Electronic address https://hdl.handle.net/11104/0350462
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