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Elevated glutathione in researchers exposed to engineered nanoparticles due to potential adaptation to oxidative stress
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SYSNO ASEP 0582145 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Elevated glutathione in researchers exposed to engineered nanoparticles due to potential adaptation to oxidative stress Author(s) Klusáčková, P. (CZ)
Lischková, L. (CZ)
Kolesnikova, V. (RU)
Navrátil, Tomáš (UFCH-W) RID, ORCID
Vlčková, Š. (CZ)
Fenclová, Z. (CZ)
Schwarz, Jaroslav (UCHP-M) RID, ORCID, SAI
Ondráček, Jakub (UCHP-M) RID, ORCID, SAI
Ondráčková, Lucie (UCHP-M) RID, ORCID, SAI
Koštejn, Martin (UCHP-M) RID, SAI, ORCID
Dvořáčková, Š. (CZ)
Rössnerová, Andrea (UEM-P) RID
Pohanka, M. (CZ)
Bradna, P. (CZ)
Ždímal, Vladimír (UCHP-M) RID, ORCID, SAI
Pelclová, D. (CZ)Source Title Nanomedicine. - : Future Medicine - ISSN 1743-5889
Roč. 19, č. 3 (2024), s. 185-198Number of pages 14 s. Language eng - English Country GB - United Kingdom Keywords adaptation ; antioxidant status ; inhalation OECD category Physical chemistry Subject RIV - cooperation Institute of Chemical Process Fundamentals - Safety, Health Protection, Human - Machine Method of publishing Open access Institutional support UFCH-W - RVO:61388955 ; UCHP-M - RVO:67985858 ; UEM-P - RVO:68378041 UT WOS 001151680900001 EID SCOPUS 85184288746 DOI 10.2217/nnm-2023-0207 Annotation Aim: To find a practical biomonitoring method for researchers exposed to nanoparticles causing oxidative stress. Methods: In a continuation of a study in 2016–2018, biological samples (plasma, urine and exhaled breath condensate [EBC]) were collected in 2019–2020 from 43 researchers (13.8 ± 3.0 years of exposure) and 45 controls. Antioxidant status was assessed using glutathione (GSH) and ferric-reducing antioxidant power, while oxidative stress was measured as thiobarbituric acid reactive substances, all using spectrophotometric methods. Researchers’ personal nanoparticle exposure was monitored. Results: Plasma GSH was elevated in researchers both before and after exposure (p < 0.01), postexposure plasma GSH correlated with nanoparticle exposure, and GSH in EBC increased. Conclusion: The results suggest adaptation to chronic exposure to nanoparticles, as monitored by plasma and EBC GSH. Workplace J. Heyrovsky Institute of Physical Chemistry Contact Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Year of Publishing 2025 Electronic address https://www.futuremedicine.com/doi/10.2217/nnm-2023-0207
Number of the records: 1