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Comparing species-different responses in pulmonary fibrosis research: Current understanding of in vitro lung cell models and nanomaterials
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SYSNO ASEP 0581653 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Comparing species-different responses in pulmonary fibrosis research: Current understanding of in vitro lung cell models and nanomaterials Author(s) Keshavan, S. (CH)
Bannuscher, A. (CH)
Drasler, B. (CH)
Barošová, Hana (UEM-P)
Petri-Fink, A. (CH)
Rothen-Rutishauser, B. (CH)Article number 183 Source Title European Journal of Pharmaceutical Sciences. - : Elsevier - ISSN 0928-0987
Roč. 183, apr. (2023)Number of pages 18 s. Language eng - English Country NL - Netherlands Keywords pulmonary fibrosis ; in vitro lung models ; adverse outcome pathway ; nanomaterials OECD category Public and environmental health Method of publishing Open access Institutional support UEM-P - RVO:68378041 UT WOS 000927781100001 EID SCOPUS 85147207609 DOI 10.1016/j.ejps.2023.106387 Annotation Pulmonary fibrosis (PF) is a chronic, irreversible lung disease that is typically fatal and characterized by an abnormal fibrotic response. As a result, vast areas of the lungs are gradually affected, and gas exchange is impaired, making it one of the world's leading causes of death. This can be attributed to a lack of understanding of the onset and progression of the disease, as well as a poor understanding of the mechanism of adverse responses to various factors, such as exposure to allergens, nanomaterials, environmental pollutants, etc. So far, the most frequently used preclinical evaluation paradigm for PF is still animal testing. Nonetheless, there is an urgent need to understand the factors that induce PF and find novel therapeutic targets for PF in humans. In this regard, robust and realistic in vitro fibrosis models are required to understand the mechanism of adverse responses. Over the years, several in vitro and ex vivo models have been developed with the goal of mimicking the biological barriers of the lung as closely as possible. This review summarizes recent progress towards the development of experimental models suitable for predicting fibrotic responses, with an emphasis on cell culture methods, nanomaterials, and a comparison of results from studies using cells from various species. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2024 Electronic address https://www.sciencedirect.com/science/article/pii/S0928098723000180?via%3Dihub
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