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Lessons from the deep: mechanisms behind diversification of eukaryotic protein complexes
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SYSNO ASEP 0580593 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Lessons from the deep: mechanisms behind diversification of eukaryotic protein complexes Author(s) Prokopchuk, Galina (BC-A) RID, ORCID
Butenko, Anzhelika (BC-A) RID, ORCID
Dacks, Joel Bryan (BC-A) SAI, ORCID
Speijer, D. (NL)
Field, Mark Christian (BC-A) ORCID
Lukeš, Julius (BC-A) RID, ORCIDNumber of authors 6 Source Title Biological Reviews. - : Wiley - ISSN 1464-7931
Roč. 98, č. 6 (2023), s. 1910-1927Number of pages 18 s. Publication form Print - P Language eng - English Country US - United States Keywords mitochondrial contact site ; cytochrome-c-oxidase ; rab gtpase family ; respiratory-chain ; acanthamoeba-castellanii ; trypanosoma-brucei ; atp synthase ; chlamydomonas-reinhardtii ; succinate-dehydrogenase ; tethering complexes ; molecular evolution ; evolutionary mechanisms ; gene replacement ; constructive neutral evolution ; protein complexes ; evolutionary divergence Subject RIV EA - Cell Biology OECD category Cell biology R&D Projects GA20-11585S GA ČR - Czech Science Foundation (CSF) GX23-06479X GA ČR - Czech Science Foundation (CSF) EF16_019/0000759 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support BC-A - RVO:60077344 UT WOS 001010386900001 EID SCOPUS 85162095919 DOI 10.1111/brv.12988 Annotation Genetic variation is the major mechanism behind adaptation and evolutionary change. As most proteins operate through interactions with other proteins, changes in protein complex composition and subunit sequence provide potentially new functions. Comparative genomics can reveal expansions, losses and sequence divergence within protein-coding genes, but in silico analysis cannot detect subunit substitutions or replacements of entire protein complexes. Insights into these fundamental evolutionary processes require broad and extensive comparative analyses, from both in silico and experimental evidence. Here, we combine data from both approaches and consider the gamut of possible protein complex compositional changes that arise during evolution, citing examples of complete conservation to partial and total replacement by functional analogues. We focus in part on complexes in trypanosomes as they represent one of the better studied non-animal/non-fungal lineages, but extend insights across the eukaryotes by extensive comparative genomic analysis. We argue that gene loss plays an important role in diversification of protein complexes and hence enhancement of eukaryotic diversity. Workplace Biology Centre (since 2006) Contact Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Year of Publishing 2024 Electronic address https://onlinelibrary.wiley.com/doi/10.1111/brv.12988
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