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Rapid identification of pathogens in blood serum via Raman tweezers in combination with advanced processing methods
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SYSNO ASEP 0579192 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Rapid identification of pathogens in blood serum via Raman tweezers in combination with advanced processing methods Author(s) Vaculík, Ondřej (UPT-D)
Bernatová, Silvie (UPT-D) RID, SAI
Rebrošová, K. (CZ)
Samek, Ota (UPT-D) RID, ORCID, SAI
Šilhan, Lukáš (UPT-D)
Růžička, F. (CZ)
Šerý, Mojmír (UPT-D) RID, SAI
Šiler, Martin (UPT-D) RID, ORCID, SAI
Ježek, Jan (UPT-D) RID, ORCID, SAI
Zemánek, Pavel (UPT-D) RID, SAI, ORCIDSource Title Biomedical Optics Express. - : Optical Society of America - ISSN 2156-7085
Roč. 14, č. 12 (2023), s. 6410-6421Number of pages 12 s. Publication form Online - E Language eng - English Country US - United States Keywords Raman tweezers ; blood serum ; Raman spectroscopy ; bloodstream infections ; diagnostics ; sepsis Subject RIV BH - Optics, Masers, Lasers OECD category Optics (including laser optics and quantum optics) R&D Projects FV40455 GA MPO - Ministry of Industry and Trade (MPO) FW06010453 GA TA ČR - Technology Agency of the Czech Republic (TA ČR) NU21-05-00341 GA MZd - Ministry of Health (MZ) Method of publishing Open access Institutional support UPT-D - RVO:68081731 UT WOS 001123729400003 EID SCOPUS 85181986022 DOI 10.1364/BOE.503628 Annotation Pathogenic microbes contribute to several major global diseases that kill millions of people every year. Bloodstream infections caused by these microbes are associated with high morbidity and mortality rates, which are among the most common causes of hospitalizations. The search for the “Holy Grail” in clinical diagnostic microbiology, a reliable, accurate, low cost, real-time, and easy-to-use diagnostic method, is one of the essential issues in clinical practice. These very critical conditions can be met by Raman tweezers in combination with advanced analysis methods. Here, we present a proof-of-concept study based on Raman tweezers combined with spectral mixture analysis that allows for the identification of microbial strains directly from human blood serum without user intervention, thus eliminating the influence of a data analyst. Workplace Institute of Scientific Instruments Contact Martina Šillerová, sillerova@ISIBrno.Cz, Tel.: 541 514 178 Year of Publishing 2024 Electronic address https://opg.optica.org/boe/fulltext.cfm?uri=boe-14-12-6410&id=542842
Number of the records: 1