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An investigation of DNA damage and DNA repair in chemical carcinogenesis triggered by small-molecule xenobiotics and in cancer: Thirty years with the comet assay
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SYSNO ASEP 0577151 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title An investigation of DNA damage and DNA repair in chemical carcinogenesis triggered by small-molecule xenobiotics and in cancer: Thirty years with the comet assay Author(s) Vodička, Pavel (UEM-P) RID
Vodenková, Soňa (UEM-P) ORCID, RID
Horák, Josef (UEM-P) ORCID
Opattová, Alena (UEM-P)
Tomášová, Kristýna (UEM-P)
Vymetálková, Veronika (UEM-P) RID
Štětina, R. (CZ)
Hemminki, K. (DE)
Vodičková, L. (CZ)Article number 503564 Source Title Mutation Research - Genetic Toxicology and Environmental Mutagenesis. - : Elsevier - ISSN 1383-5718
Roč. 885, nov. (2023)Number of pages 14 s. Language eng - English Country NL - Netherlands Keywords butadiene ; DNA damage ; DNA repair ; formaldehyde ; occupational medicine ; styrene OECD category Biochemistry and molecular biology R&D Projects LX22NPO5102 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GX21-04607X GA ČR - Czech Science Foundation (CSF) GA21-27902S GA ČR - Czech Science Foundation (CSF) NU21-03-00145 GA MZd - Ministry of Health (MZ) Method of publishing Limited access Institutional support UEM-P - RVO:68378041 UT WOS 000975174500001 EID SCOPUS 85142719387 DOI 10.1016/j.mrgentox.2022.503564 Annotation In the present review we addressed the determination of DNA damage induced by small-molecule carcinogens, considered their persistence in DNA and mutagenicity in in vitro and in vivo systems over a period of 30 years. The review spans from the investigation of the role of DNA damage in the cascade of chemical carcinogenesis. In the nineties, this concept evolved into the biomonitoring studies comprising multiple biomarkers that not only reflected DNA/chromosomal damage, but also the potential of the organism for biotransformation/elimination of various xenobiotics. Since first years of the new millennium, dynamic system of DNA repair and host susceptibility factors started to appear in studies and a considerable knowledge has been accumulated on carcinogens and their role in carcinogenesis. It was understood that the final biological links bridging the arising DNA damage and cancer onset remain to be elucidated. In further years the community of scientists learnt that cancer is a multifactorial disease evolving over several decades of individual´s life. Moreover, DNA damage and DNA repair are inseparable players also in treatment of malignant diseases, but affect substantially other processes, such as degeneration. Functional monitoring of DNA repair pathways and DNA damage response may cast some light on above aspects. Very little is currently known about the relationship between telomere homeostasis and DNA damage formation and repair. DNA damage/repair in genomic and mitochondrial DNA and crosstalk between these two entities emerge as a new interesting topic. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2024 Electronic address https://www.sciencedirect.com/science/article/abs/pii/S1383571822001267?via%3Dihub
Number of the records: 1