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Bioresorbable films of polycaprolactone blended with poly(lactic acid) or poly(lactic-co-glycolic acid)
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SYSNO ASEP 0575630 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Bioresorbable films of polycaprolactone blended with poly(lactic acid) or poly(lactic-co-glycolic acid) Author(s) Dodda, J. M. (CZ)
Azar, M. G. (CZ)
Bělský, P. (CZ)
Šlouf, Miroslav (UMCH-V) RID, ORCID
Gajdošová, Veronika (UMCH-V) RID, ORCID
Kasi, P. B. (CZ)
Anerillas, L. O. (SE)
Kovářík, T. (CZ)Article number 126654 Source Title International Journal of Biological Macromolecules. - : Elsevier - ISSN 0141-8130
Roč. 248, 1 September (2023)Number of pages 13 s. Language eng - English Country NL - Netherlands Keywords resorbable blends ; polycaprolactone ; nanoscale morphology Subject RIV CD - Macromolecular Chemistry OECD category Polymer science Method of publishing Limited access Institutional support UMCH-V - RVO:61389013 UT WOS 001079905600001 EID SCOPUS 85170288716 DOI 10.1016/j.ijbiomac.2023.126654 Annotation Recent complications on the use of polypropylene meshes for hernia repair has led to the development of meshes or films, which were based on resorbable polymers such as polycaprolactone (PCL), polylactic acid (PLA) and poly(lactic-co-glycolic acid) (PLGA). These materials are able to create suitable bioactive environment for the growth and development of cells. In this research, we mainly focused on the relations among structure, mechanical performance and biocompatiblity of PCL/PLA and PCL/PLGA and blends prepared by solution casting. The films were characterized regarding the chemical structure, morphology, physicochemical properties, cytotoxicity, biocompatibility and cell growth. All the films showed high tensile strength ranging from 9.5 to 11.8 MPa. SAXS showed that the lamellar stack structure typical for PCL was present even in the blend films while the morphological parameters of the stacks varied slightly with the content of PLGA or PLA in the blends. WAXS indicated preferential orientation of crystallites (and thus, also the lamellar stacks) in the blend films. In vitro studies revealed that PCL/PLGA films displayed better cell adhesion, spreading and proliferation than PCL/PLA and PCL films. Further the effect of blending on the degradation was investigated, to understand the significant variable within the process that could provide further control of cell adhesion. The results showed that the investigated blend films are promising materials for biomedical applications. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2024 Electronic address https://www.sciencedirect.com/science/article/pii/S0141813023035511?via%3Dihub
Number of the records: 1