Brain metabolic derangements examined using 1H MRS and their (in)consistency among different rodent models of depression

0573416 - ÚPT 2024 RIV GB eng J - Journal Article
Pavlova, Iveta - Rudá-Kučerová, J.
Brain metabolic derangements examined using 1H MRS and their (in)consistency among different rodent models of depression.
Progress in Neuro-Psychopharmacology & Biological Psychiatry. Roč. 127, 20 December (2023), č. článku 110808. ISSN 0278-5846. E-ISSN 1878-4216
R&D Projects: GA MŠMT(CZ) LM2018129; GA MŠMT(CZ) LM2023050
Institutional support: RVO:68081731
Keywords : Animal models * Depression * Proton magnetic resonance spectroscopy * Metabolites
OECD category: Biochemistry and molecular biology
Impact factor: 5.6, year: 2022
Method of publishing: Open access
https://www.sciencedirect.com/science/article/pii/S0278584623000945

Major depressive disorder (MDD) is underlined by neurochemical changes in the brain. Proton magnetic resonance spectroscopy (1H MRS) is a useful tool for their examination as it provides information about the levels of metabolites. This review summarises the current knowledge of 1H MRS findings from rodent models of MDD, assesses the results from both a biological and a technical perspective, and identifies the main sources of bias. From a technical point of view, bias-introducing factors are the diversity of the measured volumes and their positioning in the brain, the data processing, and the metabolite concentration expression. The biological variables are strain, sex, and species, as well as the model itself, and in vivo vs. ex vivo exploration. This review identified some consistency in the 1H MRS findings in the models of MDD: lower levels of glutamine, glutamate + glutamine, and higher levels of myo-inositol and taurine in most of the brain regions of MDD models. This may suggest changes in regional metabolism, neuronal dysregulation, inflammation, and a compensatory effect reaction in the MDD rodent models.
Permanent Link: https://hdl.handle.net/11104/0343908