Number of the records: 1
4-Methylumbeliferone Treatment at a Dose of 1.2 g/kg/Day Is Safe for Long-Term Usage in Rats
- 1.0571587 - FGÚ 2024 RIV CH eng J - Journal Article
Štěpánková, K. - Mareková, D. - Kubášová, K. - Sedláček, R. - Turnovcová, K. - Vacková, Irena - Kubinová, Šárka - Makovický, P. - Petrovičová, M. - Kwok, J. C. F. - Jendelová, P. - Machová-Urdzíková, L.
4-Methylumbeliferone Treatment at a Dose of 1.2 g/kg/Day Is Safe for Long-Term Usage in Rats.
International Journal of Molecular Sciences. Roč. 24, č. 4 (2023), č. článku 3799. E-ISSN 1422-0067
Institutional support: RVO:67985823 ; RVO:68378271
Keywords : hyaluronan * 4-methylumbelliferone * chondroitin sulphates * neuroplasticity
OECD category: Neurosciences (including psychophysiology; Biochemistry and molecular biology (FZU-D)
Impact factor: 5.6, year: 2022
Method of publishing: Open access
https://www.mdpi.com/1422-0067/24/4/3799
4-methylumbelliferone (4MU) has been suggested as a potential therapeutic agent for a wide range of neurological diseases. The current study aimed to evaluate the physiological changes and potential side effects after 10 weeks of 4MU treatment at a dose of 1.2 g/kg/day in healthy rats, and after 2 months of a wash-out period. Our findings revealed downregulation of hyaluronan (HA) and chondroitin sulphate proteoglycans throughout the body, significantly increased bile acids in blood samples in weeks 4 and 7 of the 4MU treatment, as well as increased blood sugars and proteins a few weeks after 4MU administration, and significantly increased interleukins IL10, IL12p70 and IFN gamma after 10 weeks of 4MU treatment. These effects, however, were reversed and no significant difference was observed between control treated and 4MU-treated animals after a 9-week wash-out period.
Permanent Link: https://hdl.handle.net/11104/0342773
File Download Size Commentary Version Access 0571587.pdf 0 9 MB CC Licence Publisher’s postprint open-access
Number of the records: 1