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Lysosomal nanotoxicity: Impact of nanomedicines on lysosomal function
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SYSNO ASEP 0571307 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Lysosomal nanotoxicity: Impact of nanomedicines on lysosomal function Author(s) Uzhytchak, Mariia (FZU-D) ORCID
Smolková, Barbora (FZU-D) ORCID
Lunova, Mariia (FZU-D) ORCID
Frtús, Adam (FZU-D) ORCID
Jirsa, M. (CZ)
Dejneka, Alexandr (FZU-D) RID, ORCID
Lunov, Oleg (FZU-D) ORCIDNumber of authors 7 Article number 114828 Source Title Advanced Drug Delivery Reviews. - : ELSEVIER SCIENCE BV - ISSN 0169-409X
Roč. 197, June (2023)Number of pages 41 s. Language eng - English Country NL - Netherlands Keywords nanomedicines ; nanoparticles ; drug-induced liver injury (DILI) ; endocytosis ; cytotoxicity ; lysosomes ; apoptosis ; autophagy ; cancer ; nanotoxicity Subject RIV BO - Biophysics OECD category Biophysics R&D Projects EF16_019/0000760 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Limited access Institutional support FZU-D - RVO:68378271 UT WOS 000989454200001 EID SCOPUS 85153295037 DOI 10.1016/j.addr.2023.114828 Annotation Although several nanomedicines got clinical approval over the past two decades, the clinical translation rate is relatively small so far. There are many post-surveillance withdrawals of nanomedicines caused by various safety issues. For successful clinical advancement of nanotechnology, it is of unmet need to realize cellular and molecular foundation of nanotoxicity. Current data suggest that lysosomal dysfunction caused by nanoparticles is emerging as the most common intracellular trigger of nanotoxicity. This review analyzes prospect mechanisms of lysosomal dysfunction-mediated toxicity induced by nanoparticles. We summarized and critically assessed adverse drug reactions of current clinically approved nanomedicines. Workplace Institute of Physics Contact Kristina Potocká, potocka@fzu.cz, Tel.: 220 318 579 Year of Publishing 2024 Electronic address http://doi.org/10.1016/j.addr.2023.114828
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