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The Role of IL-6 in Cancer Cell Invasiveness and Metastasis-Overview and Therapeutic Opportunities
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SYSNO ASEP 0565126 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title The Role of IL-6 in Cancer Cell Invasiveness and Metastasis-Overview and Therapeutic Opportunities Author(s) Rašková, M. (CZ)
Lacina, L. (CZ)
Kejík, Z. (CZ)
Venhauerová, P. (CZ)
Skaličková, S. (CZ)
Kolář, Michal (UMG-J) RID, ORCID
Jakůbek, M. (CZ)
Rosel, D. (CZ)
Smetana Jr., K. (CZ)
Brabek, J. (CZ)Number of authors 10 Article number 3698 Source Title Cells. - : MDPI
Roč. 11, č. 22 (2022)Number of pages 23 s. Publication form Online - E Language eng - English Country CZ - Czech Republic Keywords il-6 ; cancer ; metastasis Subject RIV EB - Genetics ; Molecular Biology OECD category Cell biology R&D Projects LX22NPO5102 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) EF16_019/0000785 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LM2018131 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Research Infrastructure EATRIS-CZ III - 90133 - Univerzita Palackého v Olomouci Method of publishing Open access Institutional support UMG-J - RVO:68378050 UT WOS 000887160100001 DOI 10.3390/cells11223698 Annotation Interleukin 6 (IL-6) belongs to a broad class of cytokines involved in the regulation of various homeostatic and pathological processes. These activities range from regulating embryonic development, wound healing and ageing, inflammation, and immunity, including COVID-19. In this review, we summarise the role of IL-6 signalling pathways in cancer biology, with particular emphasis on cancer cell invasiveness and metastasis formation. Targeting principal components of IL-6 signalling (e.g., IL-6Rs, gp130, STAT3, NF-kappa B) is an intensively studied approach in preclinical cancer research. It is of significant translational potential, numerous studies strongly imply the remarkable potential of IL-6 signalling inhibitors, especially in metastasis suppression. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2023 Electronic address https://www.mdpi.com/2073-4409/11/22/3698
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