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Administration of nitro-oleic acid mitigates radiation-induced hematopoietic injury in mice
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SYSNO ASEP 0564730 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Administration of nitro-oleic acid mitigates radiation-induced hematopoietic injury in mice Author(s) Perečko, Tomáš (BFU-R) RID, ORCID
Hoferová, Zuzana (BFU-R) RID
Hofer, Michal (BFU-R) RID, ORCID
Perečková, Jana (BFU-R) ORCID
Falk, Martin (BFU-R) RID, ORCIDNumber of authors 5 Article number 121106 Source Title Life Sciences. - : Elsevier - ISSN 0024-3205
Roč. 310, DEC 1 2022 (2022)Number of pages 9 s. Publication form Online - E Language eng - English Country GB - United Kingdom Keywords Acute radiation syndrome ; Bone marrow cells ; Hematopoiesis ; g-csf ; Nitrooleic acid Subject RIV FR - Pharmacology ; Medidal Chemistry OECD category Pharmacology and pharmacy R&D Projects GA19-09212S GA ČR - Czech Science Foundation (CSF) Method of publishing Limited access Institutional support BFU-R - RVO:68081707 UT WOS 000880317300001 EID SCOPUS 85140399032 DOI 10.1016/j.lfs.2022.121106 Annotation Aims: Limited number of agents that provide protection against hematopoietic acute radiation syndrome led us to the evaluation of nitro-oleic acid (NO(2)OA) as a potential protector/mitigator against radiation-induced hematopoietic injury in C57/BL6 mice. Materials and methods: NO(2)OA was administered before and after sub-lethal total body irradiation (TBI) and hematological parameters were evaluated 3 or 7 days after TBI. Key findings: Our results show that NO(2)OA significantly increase bone marrow cellularity including the granulocyte-macrophage colony-forming cells and erythroid progenitors on the 3rd day after TBI. In addition, NO(2)OA enhanced recovery of white blood cells (lymphocytes, neutrophils, and monocytes) in peripheral blood 7 days after irradiation. These effects may be in part attributed to NO(2)OA-induced granulocyte colony-stimulating factor production after TBI. On the other hand, radiation-induced impairment of peripheral red blood cells, hemoglobin, and platelets were not affected with NO(2)OA treatment up to 7 days post TBI. Significance: In conclusion, our data show that NO(2)OA significantly protects hematopoiesis after irradiation, and thus showed a high potential to act as an agent for medical radiation countermeasure. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2023 Electronic address https://www.sciencedirect.com/science/article/pii/S0024320522008062?via%3Dihub
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