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If Mendel Was Using CRISPR: Genome Editing Meets Non-Mendelian Inheritance
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SYSNO ASEP 0561342 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title If Mendel Was Using CRISPR: Genome Editing Meets Non-Mendelian Inheritance Author(s) Hudzieczek, Vojtěch (BFU-R) ORCID
Hobza, Roman (BFU-R) RID, ORCID
Cápal, Petr (UEB-Q) RID, ORCID
Šafář, Jan (UEB-Q) RID, ORCID
Doležel, Jaroslav (UEB-Q) RID, ORCIDNumber of authors 5 Article number 2202585 Source Title Advanced Functional Materials - ISSN 1616-301X
Roč. 32, č. 37 (2022)Number of pages 12 s. Publication form Online - E Language eng - English Country DE - Germany Keywords crop improvement ; epigenomes ; gene mutations ; genome editing ; Gregor Mendel ; organellar genomes ; targeted chromosomal rearrangements Subject RIV EF - Botanics OECD category Plant sciences, botany Subject RIV - cooperation Institute of Experimental Botany - Botanics R&D Projects GA22-05478S GA ČR - Czech Science Foundation (CSF) GA22-00204S GA ČR - Czech Science Foundation (CSF) EF16_019/0000827 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Limited access Institutional support BFU-R - RVO:68081707 ; UEB-Q - RVO:61389030 UT WOS 000805594300001 EID SCOPUS 85131188955 DOI 10.1002/adfm.202202585 Annotation On July 20 this year, 200th anniversary of the birth of Gregor Mendel, an Augustinian monk who laid the foundations of genetics, is celebrated. His findings provided the stepping stone for rational crop improvement based on cross breeding and selection. While this approach contributed to the development of superior varieties, its potential is limited by genetic variability available within a species and its relatives. Even though physical and chemical mutagenesis enabled the induction of new genetic variability on a large scale, random mutagenesis did not allow targeting particular genome loci. This became feasible only after the development of genome editing tools in the beginning of the 21st century and the ability to precisely edit plant genomes opened a new era in plant research and crop breeding. Mendel probably did not consider a possibility of directly modifying genetic information and the advantages which genetic engineering can bring to society. However, the basic principles of inheritance he discovered are indispensable for any effort to develop improved varieties. In this review, recent advances in plant genome editing are summarized with emphasis on non-Mendelian inheritance in the light of the need to produce more food for the growing human population. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2023 Electronic address https://onlinelibrary.wiley.com/doi/10.1002/adfm.202202585
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