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Substituted pyridopyrrolopyrimidine ribonucleosides for therapeutic uses
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SYSNO ASEP 0559903 Document Type P - Patent R&D Document Type Patent or other outcome protected by special legislation Title Substituted pyridopyrrolopyrimidine ribonucleosides for therapeutic uses Author(s) Veselovská, Lucia (UOCHB-X) ORCID
Hocek, Michal (UOCHB-X) RID, ORCID
Hajdúch, M. (CZ)
Džubák, P. (CZ)Year of issue 2022 Possible third party use of the result A - Pro využití výsledku jiným subjektem je vždy nutné nabytí licence Royalty requested A - Poskytovatel licence požaduje licenční poplatek Patent no. or utility model no. or industrial design no. US11299510 Date of the patent acceptance 12.04.2022 Name of the patent owner Ústav organické chemie a biochemie AV ČR, v. v. i. - Univerzita Palackého v Olomouci Code of the issuer name US001 - United States Patent and Trademark Office (USPTO) Alexandria Current use A - Pouze udělený (dosud nevyužívaný) patent nebo patent využívaný jeho vlastníkem Language eng - English Keywords nucleosides ; fused heterocycles ; cytostatics OECD category Medicinal chemistry R&D Projects GA16-00178S GA ČR - Czech Science Foundation (CSF) TE01020028 GA TA ČR - Technology Agency of the Czech Republic (TA ČR) NV15-31984A GA MZd - Ministry of Health (MZ) EF16_019/0000729 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support UOCHB-X - RVO:61388963 Annotation Substituted pyridopyrrolopyrimidine ribonucleosides of general formula I, wherein R is as described in the independent claim, preferably R is selected from the group comprising thiophen-3-yl, furan-2-yl, furan-3-yl, benzofuran-2-yl, methylsulfanyl, methoxy, amino, dimethylamino, methyl, and pharmaceutically acceptable salt thereof, their optical isomers and mixtures of such optical isomers. Compounds according to the invention show strong cytostatic and cytotoxic effects on cell lines of tumor origin in a wide variety of diseases including tumors of different histogenetic origin. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2023 Electronic address https://worldwide.espacenet.com/patent/search/family/065763222/publication/US11299510B2?q=US11299510B2
Number of the records: 1