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HLHS: Power of the Chick Model
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SYSNO ASEP 0557062 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title HLHS: Power of the Chick Model Author(s) Sedmera, David (FGU-C) RID, ORCID, SAI Number of authors 1 Article number 113 Source Title Journal of cardiovascular development and disease. - : MDPI
Roč. 9, č. 4 (2022)Number of pages 7 s. Language eng - English Country CH - Switzerland Keywords left atrial ligation ; left ventricular hypoplasia ; hemodynamic alteration ; myocyte proliferation ; embryonic myocardium OECD category Cardiac and Cardiovascular systems R&D Projects NU21-02-00402 GA MZd - Ministry of Health (MZ) Method of publishing Open access Institutional support FGU-C - RVO:67985823 UT WOS 000786862100001 EID SCOPUS 85129078979 DOI 10.3390/jcdd9040113 Annotation Background: Hypoplastic left heart syndrome (HLHS) is a rare but deadly form of human congenital heart disease, most likely of diverse etiologies. Hemodynamic alterations such as those resulting from premature foramen ovale closure or aortic stenosis are among the possible pathways. Methods: The information gained from studies performed in the chick model of HLHS is reviewed. Altered hemodynamics leads to a decrease in myocyte proliferation causing hypoplasia of the left heart structures and their functional changes. Conclusions: Although the chick phenocopy of HLHS caused by left atrial ligation is certainly not representative of all the possible etiologies, it provides many useful hints regarding the plasticity of the genetically normal developing myocardium under altered hemodynamic loading leading to the HLHS phenotype, and even suggestions on some potential strategies for prenatal repair. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2023 Electronic address https://www.mdpi.com/2308-3425/9/4/113
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