Number of the records: 1
Dysregulation of Microtubule Nucleating Proteins in Cancer Cells
- 1.
SYSNO ASEP 0554549 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Dysregulation of Microtubule Nucleating Proteins in Cancer Cells Author(s) Dráber, Pavel (UMG-J) RID, ORCID
Dráberová, Eduarda (UMG-J) RID, ORCIDNumber of authors 2 Article number 5638 Source Title Cancers (Basel). - : MDPI
Roč. 13, č. 22 (2021)Number of pages 16 s. Publication form Online - E Language eng - English Country CH - Switzerland Keywords gamma-tubulin expression ; beta-iii-tubulin ; differential expression ; centrosome aberrations ; cellular-distribution ; spindle organization ; binding ; actin ; gene ; localization ; cancers ; microtubule nucleation ; gamma-tubulin complexes Subject RIV EB - Genetics ; Molecular Biology OECD category Oncology R&D Projects GA19-20716S GA ČR - Czech Science Foundation (CSF) GA21-30281S GA ČR - Czech Science Foundation (CSF) LTAUSA19118 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support UMG-J - RVO:68378050 UT WOS 000724082700001 DOI 10.3390/cancers13225638 Annotation Simple Summary: The dysfunction of microtubule nucleation in cancer cells changes the overall cytoskeleton organization and cellular physiology. This review focuses on the dysregulation of the gamma-tubulin ring complex (gamma-TuRC) proteins that are essential for microtubule nucleation. Recent research on the high-resolution structure of gamma-TuRC has brought new insight into the microtubule nucleation mechanism. We discuss the effect of gamma-TuRC protein overexpression on cancer cell behavior and new drugs directed to gamma-tubulin that may offer a viable alternative to microtubule-targeting agents currently used in cancer chemotherapy. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2022 Electronic address https://www.mdpi.com/2072-6694/13/22/5638
Number of the records: 1