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Iron-doped calcium phytate nanoparticles as a bio-responsive contrast agent in 1H/31P magnetic resonance imaging
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SYSNO ASEP 0554112 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Iron-doped calcium phytate nanoparticles as a bio-responsive contrast agent in 1H/31P magnetic resonance imaging Author(s) Ziolkowska, N. (CZ)
Vít, M. (CZ)
Laga, Richard (UMCH-V) RID, ORCID
Jirák, D. (CZ)Article number 2118 Source Title Scientific Reports. - : Nature Publishing Group - ISSN 2045-2322
Roč. 12, č. 1 (2022)Number of pages 9 s. Language eng - English Country GB - United Kingdom Keywords calcium phytate nanoparticles ; bio-responsive contrast agent ; 1H/31P magnetic resonance imaging Subject RIV CD - Macromolecular Chemistry OECD category Polymer science R&D Projects NU20-08-00095 GA MZd - Ministry of Health (MZ) GA19-08176S GA ČR - Czech Science Foundation (CSF) Method of publishing Open access Institutional support UMCH-V - RVO:61389013 UT WOS 000756832600024 EID SCOPUS 85124286306 DOI 10.1038/s41598-022-06125-7 Annotation We present the MR properties of a novel bio-responsive phosphorus probe doped with iron for dual proton and phosphorus magnetic resonance imaging (1H/31P-MRI), which provide simultaneously complementary information. The probes consist of non-toxic biodegradable calcium phytate (CaIP6) nanoparticles doped with different amounts of cleavable paramagnetic Fe3+ ions. Phosphorus atoms in the phytate structure delivered an efficient 31P-MR signal, with iron ions altering MR contrast for both 1H and 31P-MR. The coordinated paramagnetic Fe3+ ions broadened the 31P-MR signal spectral line due to the short T2 relaxation time, resulting in more hypointense signal. However, when Fe3+ was decomplexed from the probe, relaxation times were prolonged. As a result of iron release, intensity of 1H-MR, as well as the 31P-MR signal increase. These 1H and 31P-MR dual signals triggered by iron decomplexation may have been attributable to biochemical changes in the environment with strong iron chelators, such as bacterial siderophore (deferoxamine). Analysing MR signal alternations as a proof-of-principle on a phantom at a 4.7 T magnetic field, we found that iron presence influenced 1H and 31P signals and signal recovery via iron chelation using deferoxamine. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2023 Electronic address https://www.nature.com/articles/s41598-022-06125-7
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