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Metal-free synthesis and self-assembly of poly(ethylene glycol) methyl ether-block-poly(.epsilon.-decalactone)-block-poly(methyl methacrylate) triblock terpolymers
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SYSNO ASEP 0553636 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Metal-free synthesis and self-assembly of poly(ethylene glycol) methyl ether-block-poly(.epsilon.-decalactone)-block-poly(methyl methacrylate) triblock terpolymers Author(s) Mundil, R. (CZ)
Zhigunov, Alexander (UMCH-V) RID, ORCID
Uchman, M. (CZ)Article number 110966 Source Title European Polymer Journal. - : Elsevier - ISSN 0014-3057
Roč. 166, 5 March (2022)Number of pages 6 s. Language eng - English Country GB - United Kingdom Keywords block copolymers ; micelles ; organocatalysis Subject RIV CD - Macromolecular Chemistry OECD category Polymer science Method of publishing Limited access Institutional support UMCH-V - RVO:61389013 UT WOS 000783242300001 EID SCOPUS 85123959252 DOI 10.1016/j.eurpolymj.2021.110966 Annotation Derived from sustainable sources, ε-decalactone (ε-DL) emerges as a renewable alternative to synthetic cyclic esters. However, its copolymerization with different monomers often requires using metal complexes potentially toxic to humans and the environment. Here, we report the synthesis and self-assembly of poly(ethylene glycol) methyl ether-block-poly(ε-decalactone)-block-poly(methyl methacrylate) (mPEG-block-PDL-block-PMMA) triblock terpolymers via two synthetic pathways using a simple phosphazene- or phosphate-based metal-free catalytic system. Our size exclusion chromatography (SEC) results showed that the two-step synthetic mechanism combining bis(4-nitrophenyl) phosphate (BNPP) and 1-tert-butyl-4,4,4-tris(dimethylamino)-2,2-bis[tris(dimethylamino)-phosphoranylidenamino]-2λ5,4λ5-catenadi(phosphazene) (t-BuP4) provided a better polymerization control than sequential copolymerization. In addition, our SAXS and AFM analysis also demonstrated that the blocks are incompatible in the terpolymers, further promoting their self-assembly into multicompartment micelles in water, as confirmed by cryo-TEM. Therefore, mPEG-block-PDL-block-PMMA triblock terpolymers may be used as both environmentally friendly alternatives to metal-catalyzed polymers and drug delivery systems. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2023 Electronic address https://www.sciencedirect.com/science/article/pii/S001430572100700X
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