Protein corona inhibits endosomal escape of functionalized DNA nanostructures in living cells

Smolková, Barbora; MacCulloch, T.; Rockwood, T.F.; Liu, M.; Henry, S.J.W.; Frtús, Adam; Uzhytchak, Mariia; Lunova, Mariia; Hof, Martin; Jurkiewicz, Piotr; Dejneka, Alexandr; Stephanopoulos, N.; Lunov, Oleg

doi:https://dx.doi.org/10.1021/acsami.1c14401

Number of the records: 1

Protein corona inhibits endosomal escape of functionalized DNA nanostructures in living cells

1.

SYSNO ASEP	0546722
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Protein corona inhibits endosomal escape of functionalized DNA nanostructures in living cells
Author(s)	Smolková, Barbora (FZU-D)_ORCID MacCulloch, T. (US) Rockwood, T.F. (US) Liu, M. (US) Henry, S.J.W. (US) Frtús, Adam (FZU-D)_ORCID Uzhytchak, Mariia (FZU-D)_ORCID Lunova, Mariia (FZU-D)_ORCID Hof, Martin (UFCH-W)_{RID, ORCID} Jurkiewicz, Piotr (UFCH-W)_{RID, ORCID} Dejneka, Alexandr (FZU-D)_{RID, ORCID} Stephanopoulos, N. (US) Lunov, Oleg (FZU-D)_{ORCID, RID}
Number of authors	13
Source Title	ACS Applied Materials and Interfaces. - : American Chemical Society - ISSN 1944-8244 Roč. 13, č. 39 (2021), s. 46375-46390
Number of pages	16 s.
Language	eng - English
Country	US - United States
Keywords	nanotechnology ; DNA nanotechnology ; cellular uptake ; protein corona ; bionano interactions ; endolysosomal escape
Subject RIV	BO - Biophysics
OECD category	Biophysics
Subject RIV - cooperation	J. Heyrovsky Institute of Physical Chemistry - Physical ; Theoretical Chemistry
R&D Projects	LTC19040 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	GX19-26854X GA ČR - Czech Science Foundation (CSF)
Method of publishing	Limited access
Institutional support	FZU-D - RVO:68378271 ; UFCH-W - RVO:61388955
UT WOS	000706187100016
EID SCOPUS	85117174736
DOI	https://doi.org/10.1021/acsami.1c14401
Annotation	DNA nanostructures (DNs) can be designed in a controlled and programmable manner, and these structures are increasingly used in a variety of biomedical applications, such as the delivery of therapeutic agents. When exposed to biological liquids, most nanomaterials become covered by a protein corona, which in turn modulates their cellular uptake and the biological response they elicit. However, the interplay between living cells and designed DNs are still not well established. Namely, there are very limited studies that assess protein corona impact on DN biological activity. Here, we analyzed the uptake of functionalized DNs in three distinct hepatic cell lines.
Workplace	Institute of Physics
Contact	Kristina Potocká, potocka@fzu.cz, Tel.: 220 318 579
Year of Publishing	2022
Electronic address	https://doi.org/10.1021/acsami.1c14401

Number of the records: 1