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Microreaction and membrane technologies for continuous single-enantiomer production: A review
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SYSNO ASEP 0545922 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Microreaction and membrane technologies for continuous single-enantiomer production: A review Author(s) Petrusová, Zuzana (UCHP-M) RID, ORCID, SAI
Slouka, Z. (CZ)
Vobecká, L. (CZ)
Polezhaev, Petr (UCHP-M) RID, ORCID, SAI
Hasal, P. (CZ)
Přibyl, M. (CZ)
Izák, Pavel (UCHP-M) RID, ORCID, SAISource Title Catalysis Reviews-Science and Engineering. - : Taylor & Francis - ISSN 0161-4940
Roč. 65, č. 3 (2023), s. 773-821Number of pages 49 s. Language eng - English Country NL - Netherlands Keywords mcrofluidics ; microreactor ; continuous flow synthesis Subject RIV CI - Industrial Chemistry, Chemical Engineering OECD category Chemical process engineering R&D Projects GA20-09980S GA ČR - Czech Science Foundation (CSF) Method of publishing Open access Institutional support UCHP-M - RVO:67985858 UT WOS 000702628000001 EID SCOPUS 85115871950 DOI 10.1080/01614940.2021.1977009 Annotation Microreaction and membrane technologies offer optimal conditions for controlling enantiomer synthesis and purification processes in continuous production, with numerous advantages over batch manufacturing. One of the many forces driving the development of such technologies for the production of single optical isomers is the need for enantiomerically pure pharmaceutical drugs because enantiomers may display opposite therapeutic effects or different treatment efficacies and side effects. Yet, despite advances in asymmetric synthesis and separation techniques, preparing enantiomerically pure compounds remains a challenging task. Here, we review the progress in microfluidics and membrane chiral separation over the last two decades. In addition to describing and critically assessing the state of the art in both disciplines, we provide an overview of their beneficial properties and characteristics for developing technologies toward producing enantiomerically pure compounds. Concomitantly, we evaluate efforts to integrate synthesis and membrane separation into a microfluidic platform and pinpoint the limiting factors that must be overcome before these platforms can be fully deployed in the industry. Workplace Institute of Chemical Process Fundamentals Contact Eva Jirsová, jirsova@icpf.cas.cz, Tel.: 220 390 227 Year of Publishing 2024 Electronic address https://www.tandfonline.com/doi/full/10.1080/01614940.2021.1977009
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