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Polymer-based drug-free therapeutics for anticancer, anti-inflammatory, and antibacterial treatment
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SYSNO ASEP 0545105 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Polymer-based drug-free therapeutics for anticancer, anti-inflammatory, and antibacterial treatment Author(s) Tavares, Marina Rodrigues (UMCH-V) ORCID, RID
Pechar, Michal (UMCH-V) RID, ORCID
Chytil, Petr (UMCH-V) RID, ORCID
Etrych, Tomáš (UMCH-V) RID, ORCIDArticle number 2100135 Source Title Macromolecular Bioscience. - : Wiley - ISSN 1616-5187
Roč. 21, č. 8 (2021)Number of pages 13 s. Language eng - English Country DE - Germany Keywords drug-free macromolecular therapeutics ; glycopolymers ; nucleotides Subject RIV CD - Macromolecular Chemistry OECD category Polymer science R&D Projects GA20-04790S GA ČR - Czech Science Foundation (CSF) NU20-08-00255 GA MZd - Ministry of Health (MZ) Method of publishing Limited access Institutional support UMCH-V - RVO:61389013 UT WOS 000651749500001 EID SCOPUS 85105974433 DOI 10.1002/mabi.202100135 Annotation This paper summarizes the area of biomedicinal polymers, which serve as nanomedicines even though they do not contain any anticancer or antiinflammatory drugs. These polymer nanomedicines with unique design are in the literature highlighted as a novel class of therapeutics called “drug-free macromolecular therapeutics.” Their therapeutic efficacy is based on the tailored multiple presentations of biologically active vectors, i.e., peptides, oligopeptides, or oligosaccharides. Thus, they enable, for example, to directly induce the apoptosis of malignant cells by the crosslinking of surface slowly internalizing receptors, or to deplete the efficacy of tumor-associated proteins. The precise biorecognition of natural binding motifs by multiple vectors on the polymer construct remains the crucial part in the designing of these drug-free nanomedicines. Here, the rationales, designs, synthetic approaches, and therapeutic potential of drug-free macromolecular therapeutics consisting of various active vectors are described in detail. Recent developments and achievements for namely B-cell lymphoma treatment, Gal-3-positive tumors, inflammative liver injury, and bacterial treatment are reviewed and highlighted. Finally, a possible future prospect within this highly exciting new field of nanomedicine research is presented. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2022 Electronic address https://onlinelibrary.wiley.com/doi/10.1002/mabi.202100135
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