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Early infection-induced natural antibody response
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SYSNO ASEP 0541608 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Early infection-induced natural antibody response Author(s) Kubelková, K. (CZ)
Hudcovic, Tomáš (MBU-M) RID, ORCID
Kozáková, Hana (MBU-M) RID, ORCID
Pejchal, J. (CZ)
Macela, A. (CZ)Article number 1541 Source Title Scientific Reports. - : Nature Publishing Group - ISSN 2045-2322
Roč. 11, č. 1 (2021)Number of pages 15 s. Language eng - English Country GB - United Kingdom Keywords live vaccine strain ; bacterium francisella-tularensis ; early protective immunity ; intracellular bacterium ; t-cells OECD category Infectious Diseases R&D Projects GA19-08294S GA ČR - Czech Science Foundation (CSF) Method of publishing Open access Institutional support MBU-M - RVO:61388971 UT WOS 000609782400062 EID SCOPUS 85100078976 DOI 10.1038/s41598-021-81083-0 Annotation There remains to this day a great gap in understanding as to the role of B cells and their products-antibodies and cytokines-in mediating the protective response to Francisella tularensis, a Gram-negative coccobacillus belonging to the group of facultative intracellular bacterial pathogens. We previously have demonstrated that Francisella interacts directly with peritoneal B-1a cells. Here, we demonstrate that, as early as 12 h postinfection, germ-free mice infected with Francisella tularensis produce infection-induced antibody clones reacting with Francisella tularensis proteins having orthologs or analogs in eukaryotic cells. Production of some individual clones was limited in time and was influenced by virulence of the Francisella strain used. The phylogenetically stabilized defense mechanism can utilize these early infection-induced antibodies both to recognize components of the invading pathogens and to eliminate molecular residues of infection-damaged self cells. Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2022 Electronic address https://www.nature.com/articles/s41598-021-81083-0
Number of the records: 1