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Gestational and pubertal exposure to low dose of di-(2-ethylhexyl) phthalate impairs sperm quality in adult mice
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SYSNO ASEP 0541390 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Gestational and pubertal exposure to low dose of di-(2-ethylhexyl) phthalate impairs sperm quality in adult mice Author(s) Dostálová, Pavla (BTO-N)
Žatecká, Eva (BTO-N)
Děd, Lukáš (BTO-N) RID
Elzeinová, Fatima (BTO-N) RID
Valášková, Eliška (BTO-N)
Kubátová, Alena (BTO-N) RID
Korenková, Vlasta (BTO-N) RID
Langerová, Lucie (BTO-N) RID
Komrsková, Kateřina (BTO-N) ORCID
Pěknicová, Jana (BTO-N) RIDNumber of authors 10 Source Title Reproductive Toxicology. - : Elsevier - ISSN 0890-6238
Roč. 96, SEP 2020 (2020), s. 175-184Number of pages 10 s. Language eng - English Country US - United States Keywords DEHP ; Fertility ; Spermatogenesis ; Steroidogenesis Subject RIV EB - Genetics ; Molecular Biology OECD category Reproductive biology (medical aspects to be 3) R&D Projects GA18-11275S GA ČR - Czech Science Foundation (CSF) GJ20-17403Y GA ČR - Czech Science Foundation (CSF) ED1.1.00/02.0109 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support BTO-N - RVO:86652036 UT WOS 000582635800019 EID SCOPUS 85087779990 DOI 10.1016/j.reprotox.2020.06.014 Annotation Di-(2-ethylhexyl)-phthalate (DEHP) is a compound widely used as a plasticizer, which can leach from plastics into the environment and thus influence human health. The aim of this study was to analyze whether exposure to an environmentally relevant dose of DEHP during mice fetal development or puberty can cause long-lasting changes detectable month/s after the last exposure. We used a DEHP concentration relevant to a daily human intake of 2.4-3 mu g/kg of body weight/day. CD1 outbred mice were treated either in utero or postnatally during puberty and analyzed in adulthood. Analyzing fertility parameters using morphometric, histologic, genomic and proteomic methods we showed that DEHP exposure leads to decreased sperm concentration and quality, in both experimental groups. Moreover, the changes in anogenital distance, seminal vesicle weight, and testicular gene expression suggest a disturbance of androgen signaling in exposed animals. In conclusion, we hereby present, that the prenatal and pubertal exposure to a low dose of DEHP negatively influenced reproductive endpoints in male mice, and some of the effects were persistent until adulthood. Workplace Institute of Biotechnology Contact Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Year of Publishing 2021 Electronic address https://www.sciencedirect.com/science/article/pii/S0890623820301738?via%3Dihub
Number of the records: 1