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Polymer materials as promoters/inhibitors of amyloid fibril formation
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SYSNO ASEP 0541039 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Polymer materials as promoters/inhibitors of amyloid fibril formation Author(s) Holubová, Monika (UMCH-V) ORCID, RID
Štěpánek, Petr (UMCH-V) RID, ORCID
Hrubý, Martin (UMCH-V) RID, ORCIDSource Title Colloid and Polymer Science - ISSN 0303-402X
Roč. 299, č. 3 (2021), s. 343-362Number of pages 20 s. Language eng - English Country DE - Germany Keywords amyloidosis ; amyloid fibrils ; polymer Subject RIV CD - Macromolecular Chemistry OECD category Polymer science R&D Projects GA19-01438S GA ČR - Czech Science Foundation (CSF) GA18-07983S GA ČR - Czech Science Foundation (CSF) Method of publishing Limited access Institutional support UMCH-V - RVO:61389013 UT WOS 000554836900001 EID SCOPUS 85088867856 DOI 10.1007/s00396-020-04710-8 Annotation Polymers are omnipresent materials that are widely used in medicine, e.g., as construction materials for medical devices or as polymer nanoparticle drug delivery systems. Therefore, their possible effects on biomolecules, such as lipids, proteins, and other molecules, present in the human body must be examined. This review addresses the effects of polymer materials (such as dendrimers, polysaccharides) on the process of amyloid fibril formation. Amyloidoses are very serious diseases that are characterized by amyloid deposition in various organs and tissues, causing their dysfunction. The treatment of amyloidoses, such as Alzheimer’s disease (AD), using polymer materials is a challenge. Studies aiming to elucidate the effects of polymers on the process of amyloid fibril formation are therefore also of key importance for understanding the process of amyloid fibril formation and amyloidoses in general. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2022 Electronic address https://link.springer.com/article/10.1007%2Fs00396-020-04710-8
Number of the records: 1