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Cdx2 Animal Models Reveal Developmental Origins of Cancers
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SYSNO ASEP 0538161 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Cdx2 Animal Models Reveal Developmental Origins of Cancers Author(s) Chawengsaksophak, Kallayanee (UMG-J) ORCID Number of authors 1 Article number 928 Source Title Genes. - : MDPI
Roč. 10, č. 11 (2019)Number of pages 15 s. Publication form Online - E Language eng - English Country CH - Switzerland Keywords metaplasia ; Cdx ; cancer ; animal models Subject RIV EB - Genetics ; Molecular Biology OECD category Developmental biology R&D Projects LO1419 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GA17-16959S GA ČR - Czech Science Foundation (CSF) Method of publishing Open access Institutional support UMG-J - RVO:68378050 UT WOS 000502296000094 DOI 10.3390/genes10110928 Annotation The Cdx2 homeobox gene is important in assigning positional identity during the finely orchestrated process of embryogenesis. In adults, regenerative responses to tissues damage can require a replay of these same developmental pathways. Errors in reassigning positional identity during regeneration can cause metaplasias-normal tissue arising in an abnormal location-and this in turn, is a well-recognized cancer risk factor. In animal models, a gain of Cdx2 function can elicit a posterior shift in tissue identity, modeling intestinal-type metaplasias of the esophagus (Barrett's esophagus) and stomach. Conversely, loss of Cdx2 function can elicit an anterior shift in tissue identity, inducing serrated-type lesions expressing gastric markers in the colon. These metaplasias are major risk factors for the later development of esophageal, stomach and colon cancer. Leukemia, another cancer in which Cdx2 is ectopically expressed, may have mechanistic parallels with epithelial cancers in terms of stress-induced reprogramming. This review will address how animal models have refined our understanding of the role of Cdx2 in these common human cancers. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2021 Electronic address https://www.mdpi.com/2073-4425/10/11/928
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