Hepatic tumor cell morphology plasticity under physical constraints in 3D cultures driven by YAP-mTOR axis

Frtús, Adam; Smolková, Barbora; Uzhytchak, Mariia; Lunova, Mariia; Jirsa, M.; Hof, Martin; Jurkiewicz, Piotr; Lozinsky, V.; Wolfová, L.; Petrenko, Y.; Kubinová, Šárka; Dejneka, Alexandr; Lunov, Oleg

doi:https://dx.doi.org/10.3390/ph13120430

Number of the records: 1

Hepatic tumor cell morphology plasticity under physical constraints in 3D cultures driven by YAP-mTOR axis

1.

SYSNO ASEP	0537345
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Hepatic tumor cell morphology plasticity under physical constraints in 3D cultures driven by YAP-mTOR axis
Author(s)	Frtús, Adam (FZU-D)_ORCID Smolková, Barbora (FZU-D)_ORCID Uzhytchak, Mariia (FZU-D)_ORCID Lunova, Mariia (FZU-D)_ORCID Jirsa, M. (CZ) Hof, Martin (UFCH-W)_{RID, ORCID} Jurkiewicz, Piotr (UFCH-W)_{RID, ORCID} Lozinsky, V. (RU) Wolfová, L. (CZ) Petrenko, Y. (UA) Kubinová, Šárka (FZU-D)_{RID, ORCID} Dejneka, Alexandr (FZU-D)_{RID, ORCID} Lunov, Oleg (FZU-D)_ORCID
Number of authors	13
Article number	430
Source Title	Pharmaceuticals. - : MDPI Roč. 13, č. 12 (2020), s. 1-25
Number of pages	25 s.
Language	eng - English
Country	CH - Switzerland
Keywords	mechanotransduction ; YAP ; mTOR ; autophagy ; 3D cultures ; cytoskeleton ; cell plasticity
Subject RIV	BO - Biophysics
OECD category	Biophysics
Subject RIV - cooperation	J. Heyrovsky Institute of Physical Chemistry - Physical ; Theoretical Chemistry
R&D Projects	LTC19040 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Method of publishing	Open access
Institutional support	FZU-D - RVO:68378271 ; UFCH-W - RVO:61388955
UT WOS	000602349300001
EID SCOPUS	85097084397
DOI	10.3390/ph13120430
Annotation	Recent studies undoubtedly show that the mammalian target of rapamycin (mTOR) and the Hippo–Yes-associated protein 1 (YAP) pathways are important mediators of mechanical cues. The crosstalk between these pathways as well as de-regulation of their signaling has been implicated in multiple tumor types, including liver tumors. Additionally, physical cues from 3D microenvironments have been identified to alter gene expression and di erentiation of di erent cell lineages. However, it remains incompletely understood how physical constraints originated in 3D cultures a ect cell plasticity and what the key mediators are of such process. In this work, we use collagen sca olds as a model of a soft 3D microenvironment to alter cellular size and study the mechanotransduction that regulates that process.
Workplace	Institute of Physics
Contact	Kristina Potocká, potocka@fzu.cz, Tel.: 220 318 579
Year of Publishing	2021
Electronic address	http://hdl.handle.net/11104/0315072

Number of the records: 1