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NeuroPsychopharmacotherapy
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SYSNO ASEP 0535914 Document Type M - Monograph Chapter R&D Document Type The record was not marked in the RIV Title Anti-convulsant agents: Cortisone and Adrenocorticotropic Hormone (ACTH) Author(s) Kubová, Hana (FGU-C) RID, ORCID
Jiruška, Přemysl (FGU-C) RID, ORCID, SAI
Komárek, V. (CZ)Source Title NeuroPsychopharmacotherapy. - Cham : Springer, 2020 / Riederer Peter ; Laux Gerd ; Nagatsu Toshiharu - ISBN 978-3-319-56015-1 Pages s. 1-15 Number of pages 15 s. Publication form Online - E Language eng - English Country CH - Switzerland Keywords infantile spasms ; adrenocorticotropic hormone ; corticoids Subject RIV FH - Neurology OECD category Neurosciences (including psychophysiology Institutional support FGU-C - RVO:67985823 DOI 10.1007/978-3-319-56015-1_305-1 Annotation Adrenocorticotropic hormone (ACTH) and corticoids represent the first-line treatment of the infantile spasms-West syndrome. The exact cellular and network mechanisms behind the anti-epileptic effect of ACTH and corticoids are not known. In the brain, these substances display multiple effects ranging from controlling inflammation, brain maturation, and cellular proliferation to the modulation of several neurotransmitter systems. ACTH and corticoids display multiple systemic effects on the body mainly on glucose metabolism and immune system. Therefore, their administration is associated with increased risk of severe side effects. ACTH and steroids display nearly identical efficacy in controlling infantile spasms. The popularity of corticoids in the treatment of infantile spasms is increasing due to their advantages which include oral route of administration, lower risk of side effects, and low cost. Apart from infantile spasms, corticoids are also used in the treatment of other epileptic syndromes in childhood including Lennox-Gastaut syndrome, Landau-Kleffner syndrome, or electrical status epilepticus in sleep syndrome. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2025 Electronic address https://link.springer.com/referenceworkentry/10.1007%2F978-3-319-56015-1_305-1
Number of the records: 1