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Designed boron‐rich polymeric nanoparticles based on nano‐ion pairing for boron delivery
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SYSNO ASEP 0534511 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Designed boron‐rich polymeric nanoparticles based on nano‐ion pairing for boron delivery Author(s) Li, J. (CZ)
Janoušková, Olga (UMCH-V) RID, SAI, ORCID
Fernandez-Alvarez, R. (CZ)
Mesíková, S. (CZ)
Tošner, Z. (CZ)
Kereiche, S. (CZ)
Uchman, M. (CZ)
Matějíček, P. (CZ)Source Title Chemistry - A European Journal. - : Wiley - ISSN 0947-6539
Roč. 26, č. 63 (2020), s. 14283-14289Number of pages 7 s. Language eng - English Country DE - Germany Keywords boron neutron capture therapy ; boron cluster compounds ; nano-ions Subject RIV CD - Macromolecular Chemistry OECD category Polymer science Method of publishing Limited access Institutional support UMCH-V - RVO:61389013 UT WOS 000574858000001 EID SCOPUS 85092046204 DOI 10.1002/chem.202001699 Annotation Boron‐rich particles with the boron fraction ca.10–20 wt % of controllable shape and size that can be easily prepared via simple ion co‐assembly are promising material for tumor treatment by boron neutron capture therapy. Electroneutral, dynamic core‐shell polymeric nanoparticles were prepared by co‐assembly of cationic PEO‐block‐PGEA diblock copolymer with sodium closo‐dodecaborate, Na2[B12H12]. This is the first example of polymer nanoparticles based on [B12H12]2−nano‐ion pairing. The high [B12H12]2− loading is proven by calorimetry at physiological salt concentration. As a result of rational design, rod‐, worm‐ and sphere‐like particles were produced and further tested using human glioblastoma and cervical carcinoma cell lines. Rod‐like particles yielded the highest internalization capability in all tested cell lines. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2021 Electronic address https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202001699
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