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The formation of the atrioventricular conduction axis is linked in development to ventricular septation
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SYSNO ASEP 0534376 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title The formation of the atrioventricular conduction axis is linked in development to ventricular septation Author(s) Kvasilová, A. (CZ)
Olejníčková, Veronika (FGU-C) RID, ORCID, SAI
Jensen, B. (NL)
Christoffels, V. M. (NL)
Kolesová, H. (CZ)
Sedmera, David (FGU-C) RID, ORCID, SAI
Gregorovičová, Martina (FGU-C) RID, ORCID, SAIArticle number jeb229278 Source Title Journal of Experimental Biology. - : Company of Biologists - ISSN 0022-0949
Roč. 223, č. 19 (2020)Number of pages 5 s. Language eng - English Country GB - United Kingdom Keywords turtle ; crocodile ; chicken ; heart ; emryo Subject RIV FP - Other Medical Disciplines OECD category Anatomy and morphology (plant science to be 1.6) R&D Projects LM2015062 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) EF16_013/0001775 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LTC17023 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GA16-02972S GA ČR - Czech Science Foundation (CSF) Method of publishing Limited access Institutional support FGU-C - RVO:67985823 UT WOS 000582938000020 EID SCOPUS 85092886513 DOI 10.1242/jeb.229278 Annotation During development, the ventricles of mammals and birds acquire a specialized pattern of electrical activation with the formation of the atrioventricular conduction system (AVCS), which coincides with the completion of ventricular septation. We investigated whether AVCS formation coincides with ventricular septation in developing Siamese crocodiles (Crocodylus siamensis). Comparisons were made with Amazon toadhead turtle (Mesoclemmys heliostemma) with a partial septum only and no AVCS (negative control) and with chicken (Gallus gallus) (septum and AVCS, positive control). Optical mapping of the electrical impulse in the crocodile and chicken showed a similar developmental specialization that coincided with full ventricular septation, whereas in the turtle the ventricular activation remained primitive. Co-localization of neural marker human natural killer-1 (HNK-1) and cardiomyocyte marker anti-myosin heavy chain (MF20) identified the AVCS on top of the ventricular septum in the crocodile and chicken only. AVCS formation is correlated with ventricular septation in both evolution and development. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2021 Electronic address https://jeb.biologists.org/content/223/19/jeb229278
Number of the records: 1