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A nanocomposite layer on the basis of collagen nanofibers, and a method of preparation thereof

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    SYSNO ASEP0533071
    Document TypeP - Patent
    R&D Document TypePatent or other outcome protected by special legislation
    TitleA nanocomposite layer on the basis of collagen nanofibers, and a method of preparation thereof
    Author(s) Suchý, Tomáš (USMH-B) RID, ORCID, SAI
    Šupová, Monika (USMH-B) RID, ORCID, SAI
    Denk, František (USMH-B) ORCID
    Rýglová, Šárka (USMH-B) RID, ORCID, SAI
    Žaloudková, Margit (USMH-B) RID
    Sucharda, Zbyněk (USMH-B)
    Ballay, R. (CZ)
    Horný, L. (CZ)
    Čejka, Z. (CZ)
    Pokorný, M. (CZ)
    Knotková, K. (CZ)
    Velebný, V. (CZ)
    Year of issue2020
    Publication formPrint - P
    Possible third party use of the resultA - Pro využití výsledku jiným subjektem je vždy nutné nabytí licence
    Royalty requestedZ - Poskytovatel licence nepožaduje v některých případech licenční poplatek
    Patent no. or utility model no. or industrial design no.EP3311854
    Date of the patent acceptance05.08.2020
    Name of the patent ownerÚstav struktury a mechaniky hornin AV ČR, v. v. i. - České vysoké učení technické v Praze, Fakulta strojní - ProSpon spol. s.r.o. - Contipro a.s.
    Code of the issuer nameEPO_1 - European Patent Office Munich, The Hague, Berlin, Vienna, Brusselshttp://www.epo.org/
    Current useA - Pouze udělený (dosud nevyužívaný) patent nebo patent využívaný jeho vlastníkem
    Languageeng - English
    KeywordsCollagen ; Layer ; Composite ; Nanofiber ; Electrospining
    Subject RIVJI - Composite Materials
    OECD categoryBioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials
    R&D ProjectsTA04010330 GA TA ČR - Technology Agency of the Czech Republic (TA ČR)
    Institutional supportUSMH-B - RVO:67985891
    AnnotationThe subject of the invention is a bioactive nanocomposite layer prepared by the combination of electrospinning and electroblowing of a collagen solution comprising hydroxyapatite nanoparticles and poly(ethylene oxide), where, after the preparation and the crosslinking, the layer consists of 75 to 100 wt. % of collagen type I fibres, 5 - 15 wt. % of hydroxyapatite, and 0 - 1 wt. % of poly(ethylene oxide). The subject of this invention is also a method of production of said layer and a method of depositing antibiotics for a more effective releasing thereof without increasing the cytotoxicity. Said method comprises the impregnation of crosslinked sterilized collagen/hydroxyapatite layers with antibiotics in the form of a solution. The subject of the invention also comprises orthopaedic and dental implants based on metal or metal alloys, electrostatically coated with said composite layer based on collagen nanofibers with integrated hydroxyapatite nanoparticles and an antibiotic or a combination of antibiotics.
    WorkplaceInstitute of Rock Structure and Mechanics
    ContactIva Švihálková, svihalkova@irsm.cas.cz, Tel.: 266 009 216
    Year of Publishing2021
    Electronic addresshttps://worldwide.espacenet.com/publicationDetails/originalDocument?FT=D&date=20200805&DB=&locale=en_EP&CC=EP&NR=3311854B1&KC=B1&ND=1#
Number of the records: 1  

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