Number of the records: 1
A nanocomposite layer on the basis of collagen nanofibers, and a method of preparation thereof
- 1.
SYSNO ASEP 0533071 Document Type P - Patent R&D Document Type Patent or other outcome protected by special legislation Title A nanocomposite layer on the basis of collagen nanofibers, and a method of preparation thereof Author(s) Suchý, Tomáš (USMH-B) RID, ORCID, SAI
Šupová, Monika (USMH-B) RID, ORCID, SAI
Denk, František (USMH-B) ORCID
Rýglová, Šárka (USMH-B) RID, ORCID, SAI
Žaloudková, Margit (USMH-B) RID
Sucharda, Zbyněk (USMH-B)
Ballay, R. (CZ)
Horný, L. (CZ)
Čejka, Z. (CZ)
Pokorný, M. (CZ)
Knotková, K. (CZ)
Velebný, V. (CZ)Year of issue 2020 Publication form Print - P Possible third party use of the result A - Pro využití výsledku jiným subjektem je vždy nutné nabytí licence Royalty requested Z - Poskytovatel licence nepožaduje v některých případech licenční poplatek Patent no. or utility model no. or industrial design no. EP3311854 Date of the patent acceptance 05.08.2020 Name of the patent owner Ústav struktury a mechaniky hornin AV ČR, v. v. i. - České vysoké učení technické v Praze, Fakulta strojní - ProSpon spol. s.r.o. - Contipro a.s. Code of the issuer name EPO_1 - European Patent Office Munich, The Hague, Berlin, Vienna, Brusselshttp://www.epo.org/ Current use A - Pouze udělený (dosud nevyužívaný) patent nebo patent využívaný jeho vlastníkem Language eng - English Keywords Collagen ; Layer ; Composite ; Nanofiber ; Electrospining Subject RIV JI - Composite Materials OECD category Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials R&D Projects TA04010330 GA TA ČR - Technology Agency of the Czech Republic (TA ČR) Institutional support USMH-B - RVO:67985891 Annotation The subject of the invention is a bioactive nanocomposite layer prepared by the combination of electrospinning and electroblowing of a collagen solution comprising hydroxyapatite nanoparticles and poly(ethylene oxide), where, after the preparation and the crosslinking, the layer consists of 75 to 100 wt. % of collagen type I fibres, 5 - 15 wt. % of hydroxyapatite, and 0 - 1 wt. % of poly(ethylene oxide). The subject of this invention is also a method of production of said layer and a method of depositing antibiotics for a more effective releasing thereof without increasing the cytotoxicity. Said method comprises the impregnation of crosslinked sterilized collagen/hydroxyapatite layers with antibiotics in the form of a solution. The subject of the invention also comprises orthopaedic and dental implants based on metal or metal alloys, electrostatically coated with said composite layer based on collagen nanofibers with integrated hydroxyapatite nanoparticles and an antibiotic or a combination of antibiotics. Workplace Institute of Rock Structure and Mechanics Contact Iva Švihálková, svihalkova@irsm.cas.cz, Tel.: 266 009 216 Year of Publishing 2021 Electronic address https://worldwide.espacenet.com/publicationDetails/originalDocument?FT=D&date=20200805&DB=&locale=en_EP&CC=EP&NR=3311854B1&KC=B1&ND=1#
Number of the records: 1