Lipidated peptides for lowering blood glucose

0523564 - ÚOCHB 2020 RIV eng P - Patent Document
Maletínská, Lenka - Železná, Blanka - Kuneš, Jaroslav - Pražienková, Veronika
Lipidated peptides for lowering blood glucose.
2019. Owner: Ústav organické chemie a biochemie AV ČR, v. v. i. - Fyziologický ústav AV ČR, v. v. i. Date of the patent acceptance: 16.07.2019. Patent Number: US10350271
R&D Projects: GA TA ČR(CZ) TE01020028
Institutional support: RVO:61388963 ; RVO:67985823
Keywords : prolactin-releasing peptide * lipidated * diabetes
OECD category: Pharmacology and pharmacy; Endocrinology and metabolism (including diabetes, hormones) (FGU-C)
https://worldwide.espacenet.com/publicationDetails/originalDocument?CC=US&NR=10350271B2&KC=B2&FT=D&ND=4&date=20190716&DB=&locale=en_EP#

Lipidated analogs of prolactin-releasing peptides (PrRP) and their use in controlling and lowering blood glucose in mammals is disclosed. Useful compounds included lipidated analogs of PrRP20 and PrRP31. Pharmacological effects are demonstrated both in vitro and in vivo. Peripheral administration of the lipidated peptides towers blood glucose levels. These treatments are applicable for treating impaired glucose tolerance (IGT), and glucose intolerance condition. The disclosed compounds have application in treating medical conditions including diabetes, pre-diabetes, eating disorders, and obesity.
Permanent Link: http://hdl.handle.net/11104/0307904